Cardiovascular magnetic resonance (CMR) is a versatile technology that permits robust characterization of cardiovascular disease. The accuracy of the diagnostic information facilitates matching the patient to the “right” treatment and thereby streamline care. The ability of CMR to establish the correct diagnosis as well as quantify future risk offers unique advantages compared to other modalities. A particularly useful application of CMR is its ability to detect and quantify disease related to the myocardium that is difficult to otherwise detect. For example, CMR can detect clinically unrecognized myocardial infarction, infiltrative disease related to excess iron, glycosphingolipid, or amyloid protein. Our group has focused on myocardial fibrosis which results from varying degrees of excess collagen. Myocardial fibrosis appears to be a reversible indicator of myocardial health that is prevalent and predicts adverse events (e.g., mortality or hospitalization for heart failure) in proportion to its severity. We are attempting to understand its optimal measurement, its association with other conditions, its impact on prognosis, and its response to therapy.