Department of Medicine

Department of Medicine

  Division of Cardiology

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photo Jie Liu, PhD

Visiting Research Associate Professor of Medicine


Phone: 412-383-7305

Office: 450 Bridgeside Point I
100 Technology Drive
Pittsburgh, PA 15219
Phone: 412-383-7305
Fax: 412-383-9055
Education and Training
PhD, Academy of Military Medical Sciences, Beijing, China, 1987
BS, Heilongjiang University, Harbin, China, 1987
Postdoctoral, Molecular Cardiology, University of Texas Medical Branch, Galveston, TX, 1997
Research Fellow, Metabolic Diseases, NIDDK-NIH, Bethesda, MD, 2001
Research Interest
Mitochondrial function in the context of stem cells, growth, and metabolism

Vascular Biology

Genetic imprinting of the stimulatory G protein alpha-subunit in human genetic disease psuedohypoparathyroidism type IB
For my complete bibliography, Click Here.
Selected Publications:
Liu J, Cao L, Chen J, Song S, Lee IH, Quijano C, Liu H, Keyvanfar K, Chen H, Cao LY, Ahn BH, Kumar NG, Rovira II, XU XL, van Lohuizen M, Motoyama N, Deng CX, Finkel T. Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature. 2009; 459(7245): 387-392.
Wu JJ, Liu J, Chen EB, Wang JJ, Cao L, Narayan N, Fergusson MM, Rovira II, Allen M, Springer DA, Lago CU, Zhang S, DuBois W, Ward T, deCabo R, Gavrilova O, Mock B, Finkel T. Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Reports. 2013; 4(5): 913-920.
Pan X, Liu J, Nguyen T, Liu C, Sun J, Teng Y, Fergusson MM, Rovira II, Allen M, Springer DA, Aponte AM, Gucek M, Balaban RS, Murphy E, Finkel T. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nature Cell Biology. 2013; 15(12): 1464-1472.
Liu JC, Liu J, Holmström KM, Menazza S, Parks RJ, Fergusson MM, Yu ZX, Springer DA, Halsey C, Liu C, Murphy E, Finkel T. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Reports. 2016; 16(6): 1561-1573.
Liu S, Liu J, Ma Q, Cao L, Fattah RJ, Yu Z, Bugge TH, Finkel T, Leppla SH. Solid tumor therapy by selectively targeting stromal endothelial cells. Proceedings of the National Academy of Science USA. 2016; 113(28): E4079-E4087.
Liu S, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013; 501(7465): 63-68.
Torisu T, Torisu K, Lee IH, Liu J, Malide D, Combs CA, Wu XS, Rovira II, Fergusson MM, Weigart R, Connelly PS, Daniels MP, Komatsu M, Cao L, Finkel T. Autophagy regulates endothelial cell processing, maturation and secretion of von Willebrand factor. Nature Medicine. 2013; 19(10): 1281-1287.
Liu J, Chen M, Deng C, Bourc'his D, Nealon JG, Erlichman B, Bestor TH, Weinstein LS. Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit. Proceedings of the National Academy of Science USA. 2005; 102(15): 5513-5518.
Liu J, Nealon JG, Weinstein LS. Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB. Human Molecular Genetics. 2005; 14(1): 95-102.
Liu J, Litman D, Rosenberg MJ, Yu S, Biesecker LG, Weinstein LS. A GNAS1 imprinting defect in pseudohypoparathyroidism type IB. Journal of Clinical Investigation. 2000; 106(9): 1167-1174.
Notable Achievements
NHLBI Core Innovation Award, 2017
United States Government Service Award (Brown Medal), 2016
NHLBI Orloff Innovations Award, 2016
NHLBI Director's Award for Outstanding Translational Science, 2015
NHLBI Division of Intramural Research Orloff Science Award, 2013