Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Fadi Lakkis, MD

Frank & Athena Sarris Chair in Transplantation Biology

Professor of Surgery, Immunology and Medicine

Scientific Director, Thomas E. Starzl Transplantation Institute


Phone: 412-383-5774

Office: 200 Lothrop Street
Biomedical Science Tower, W1548
Pittsburgh, PA 15261
Phone: 412-383-5774
Education and Training
MD, American University of Beirut
Research Interest
The goal of my research is to understand the fundamental mechanisms of acute and chronic rejection in solid organ transplantation. The principal areas of investigation in my laboratory are the innate mechanisms responsible for initiating and perpetuating the alloimmune response and the role of memory T cells in allograft rejection. Mouse models of skin, heart, kidney, and islet transplantation are employed to address these areas of investigation. Intravital multiphoton microscopy is used to investigate the mechanisms of monocyte and memory T cell migration to the transplanted mouse kidney. My lab is also part of a human immunology group investigating innate and adaptive immune function in kidney transplant recipients.
For my complete bibliography, Click Here.
Selected Publications:
Hautz, T., Zelger, B.G., Nasr, I.W., Mundinger, G.S., Barth, R.N., Rodriguez, E.D., Brandacher, G., Weissenbacher, A., Zelger, B., Cavadas, P., Margreiter, R., Lee, W.P., Pratschke, J., Lakkis, F.G., Schneeberger, S. Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts. Transplant International. 2014; 27(9): 966-76.
Oberbarnscheidt, M.H., Zeng, Q., Li, Q., Dai, H., Williams, A.L., Shlomchik, W.D., Rothstein, D.M., Lakkis, F.G. Non-self recognition by monocytes initiates allograft rejection. Journal of Clinical Investigation. 2014; 124(8): 3579-89.
Camirand, G., Wang, Y., Lu, Y.Y., Wan, Y.Y., Lin, Y., Deng, S., Guz, G., Perkins, D.L., Finn, P.W., Farber, D.L., Flavell, R.A., Shlomchik, W.D., Lakkis, F.G., Rudd, C.E., Rothstein, D.M. CD45 ligation expands Tregs by promoting interactions with DCs. Journal of Clinical Investigation. 2014; 124(10: 4603-13.
Zhuang, Q., Lakkis, F.G. Dendritic cells and innate immunity in kidney transplantation. Kidney International. 2015; 87(4): 12-8.
Yatim, K.M., Lakkis, F.G. A brief journey through the immune system. Clinical Journal of the American Society of Nephrology. 2015; 10(7): 1274-81.
Lakkis, F.G., Palevsky, P.M. A new CJASN series: renal immunology for the clinician. Clinical Journal of the American Society of Nephrology. 2015; 10(7): 1273.
Hoffman, W., Lakkis, F.G., Chalasani, G. B Cells, Antibodies, and More. Clinical Journal in American Nephrology. 2016; 11(1): 137-54.
Zhang, Q., Lakkis, F.G. Memory T Cell Migration. Frontiers in Immunology. 2015; 6: 504.
Thomson, A.W., Zahorchak, A.F., Ezzelarab, M.B., Butterfield, L.H., Lakkis, F.G., Metes, D.M. Prospective Clinical Testing of Regulatory Dendritic Cells in Organ Transplantation. Frontiers in Immunology. 2016; 7: 15.
Zhang, Q., Dai, H., Yatim, K.M., Abou-Daya, K., Williams, A.L., Oberbarnscheidt, M.H., Camirand, G., Rudd, C.E., Lakkis, F.G. CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells. Journal of Immunology. 2016.