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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Marcelo D. Carattino, PhD

Associate Professor of Medicine

Associate Professor of Cell Biology

Director of the Cellular Physiology Core of the Pittsburgh Center for Kidney Research

Email: mdc4@pitt.edu

Phone: 412-648-9075

Contact
Office: 3550 Terrace Street
S935 Scaife Hall
Pittsburgh, PA 15261
 
Phone: 412-648-9075
Fax: 412-383-8956
E-mail: mdc4@pitt.edu
Education and Training
Education
B.S./M.Sc, University of Buenos Aires, Argentina, 1995
PhD, University of Buenos Aires, Argentina, 2001
Training
Postdoc, University of Pittsburgh, 2004
Research Interest
Dr. Carattino's lab is focused on studying the function of acid-sensing ion channels (ASICs). These channels are expressed in the nervous system where they contribute to sensory processes such as mechanosensation and nociception. The goals of our research program are to elucidate the molecular basis underlying the function of ASICs and to identify targets in these proteins that can be used to develop inhibitors. A second area of research in our lab examines the role of the urothelial barrier in interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic voiding disorder with symptoms that include urinary frequency and pain in the bladder and/or pelvis. Although the exact cause of IC/BPS is unknown, numerous lines of evidence suggest that an increase in the permeability of the urothelium contributes to the symptoms in this condition. The goal of this project is to examine the mechanisms that mediate voiding symptoms and pain in an animal model with reduced urothelial barrier function, providing a rational foundation to treat hypersensitive bladder disorders.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Carattino MD, Sheng S, Kleyman TR. Epithelial Na+ channels are activated by laminar shear stress. The Journal of Biological Chemistry. 2004; 279: 4120-6.
Carattino MD, Sheng S, Bruns JB, Pilewski JM, Hughey RP, Kleyman TR. The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit. The Journal of Biological Chemistry. 2006; 281 (27): 18901-7.
Carattino MD, Hughey RP, Kleyman TR. Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. The Journal of Biological Chemistry. 2008; 283 (37): 25290-5.
Della Vecchia MC, Rued C, Carattino MD. Gating transitions in the palm domain of ASIC1a. Journal of Biological Chemistry. 2013; 288 (8): 5487-95.
Carattino MD, Prakasam HS, Ruiz WG, Clayton DR, McGuire M, Gallo LI, Apodaca G. Bladder filling and voiding affect umbrella cell tight junction organization and function. Am J Physiol Renal Physiol. 2013; 305 (8): F1158-68.
Krauson AJ, Rued AC, Carattino MD. Independent contribution of extracellular proton binding sites to ASIC1a activation. Journal of Biological Chemistry. 2013; 288 (48): 34375-83.
Montalbetti N, Rued AC,, Clayton DR, Ruiz WG, Bastacky SI, Prakasam HS, Eaton AF, Kullmann FA, Apodaca G, Carattino MD. Increased urothelial paracellular transport promotes cystitis. Am J Physiol Renal Physiol. 2015; 309 12): F1070-81.
Webb TN, Carrisoza-Gaytan R, Montalbetti N, Rued A, Roy A, Socovich AM, Subramanya AR, Satlin LM, Kleyman TR, Carattino MD. Webb TN, Carrisoza-Gaytan R, Montalbetti N, Rued A, Roy A, Socovich AM, Subramanya AR, Satlin LM, Kleyman TR, Carattino MD. Am J Physiol Renal Physiol. 2016; 310(1): F15-26.
Sponsored Research/Activities
Title: Conformational Rearrangements Underlying ASIXC1a Gatting
Role: Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK084060
Start Year: 2010
End Year: 2016
Title: Biology and Function of the Bladder Umbrella Cell Paracellular Barrier
Role: Co-Principal Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK099196
Start Year: 2013
End Year: 2018
Title: Maturation of K Transport in the Distal Nephron
Role: Co-Investigator
Funding Agency: Mt. Sinai Medical Center/National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK038470
Start Year: 2015
End Year: 2020
Title: Flow-Stimulated Endocytosis in the Proximal Tubule
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: R01 DK101484
Start Year: 2014
End Year: 2018
Title: Pittsburgh Center for Kidney Research - Core A
Role: Core Director
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Notable Achievements
Member, The American Physiological Society, 2004-present
Member, The American Society of Nephrology, 2008-present
Member, The Biophysical Society, 2012-present
Member, Society for Neuroscience, 2016-present
American Heart Association, Postdoctoral Fellowship, 2002-2004
Carl W. Gottschalk Research Scholar of the American Society of Nephrology, 2008-2010
The American Physiological Society, Lazaro J. Mandel Young Investigator Award, 2012