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Department of Medicine

Department of Medicine

 Division of Renal-Electrolyte

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photo Cary Boyd-Shiwarski, MD, PhD

Post-Doctoral Scholar

Email: boydcr@upmc.edu

Phone: 412-647-3118

Contact
Office: A919 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-647-3118
Fax: 412-648-9166
E-mail: boydcr@upmc.edu
Education and Training
Education
BS, University of Arizona, 2001
PhD, Dartmouth College, 2007
MD, University of Pittsburgh, 2012
Training
Internal Medicine Residency, University of Pittsburgh Medical Center, 2014
Renal-Electrolyte Fellowship Training Program, University of Pittsburgh Medical Center, 2016
Research Interest
Dr. Boyd-Shiwarski’s research interests are potassium homeostasis and ion transport, with a focus on the regulation of the NCC (sodium-chloride cotransporter) by WNK (With-No-Lysine) kinases. WNK kinases are the only known kinases that directly bind chloride and act as regulators of potassium homeostasis. Her recent studies of have focused on the role of a kidney specific isoform of WNK1 in localizing WNK kinases to a protein complex.
Clinical Interest
I am interested in the clinical management of hypertension. Hypertension is the main risk factor for cardiovascular disease and stroke, and has become a global epidemic and the leading cause of death and disability-adjusted life years. Therefore, the prevention and treatment of hypertension is of vital importance. I am also interested in treating patients with inherited disorders that may lead to electrolyte imbalances and hypertension.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Ray EC, Rondon-Berrios H, Boyd CR, Kleyman TR. Sodium retention and volume expansion in nephrotic syndrome: implications for hypertension. Advances in Chronic Kidney Discovery. 2014; 22(3): 179-84.
Kashlan OB, Boyd CR, Argyropoulos C, Okumura S, Hughey RP, Grabe M, Kleyman TR. Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. Journal of Biological Chemistry. 2010; 285(45): 35216-123.
Buck TM, Kolb AR, Boyd CR, Kleyman TR, Brodsky JL. The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Molecular Biology of the Cell. 2010; 21(6): 1047-58.
Maarouf AB, Sheng N, Chen J, Winarski KL, Okumura S, Carattino MD, Boyd CR, Kleyman TR, Sheng S. Novel determinants of epithelial sodium channel gating within extracellular thumb domains. Journal of Biological Chemistry. 2009; 284(12): 7756-65.
Náray-Fejes-Tóth A, Boyd C, Fejes-Tóth G. Regulation of epithelial sodium transport by promyelocytic leukemia zinc finger protein. American Journal Physiology Renal Physiology. 2008; 295(1): F18-26.
Boyd C, Náray-Fejes-Tóth A. Steroid-mediated regulation of the epithelial sodium channel subunits in mammary epithelial cells. Endocrinology. 2007; 148(8): 3958-67.
Boyd C, Náray-Fejes-Tóth A. Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1. American Journal of Physiology Renal Physiology. 2005; 288(3): F505-12.
Swiatecka-Urban A, Boyd C, Coutermarsh B, Karlson KH, Barnaby R, Aschenbrenner L, Aschenbrenner L, Langford GM, Hasson T, Stanton BA. Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator. Journal of Biological Chemistry. 2004; 279(36): 38025-31.
Notable Achievements
Renal Fellows Teaching Award, 2016
ASN Ben J. Lipps Research Fellowship, 2016