SCHOOL OF MEDICINE  |  PITT HOME  |  FIND PEOPLE  |  FIND A DOCTOR AT UPMC

Department of Medicine

Department of Medicine

  PhD Community

PhD Community Member



Members:

Patrick J. Pagano, PhD

Professor, VMI
E1247 BST
200 Lothrop Street
Pittsburgh, PA 15261

Email: pagano@pitt.edu



Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
What are the signaling mechanisms regulating NADPH oxidase (Nox) action and vascular cell phenotype?

How are Noxs involved in the pathogenesis of cardiovascular & pulmonary diseases?

Can we design new isoform-specific inhibitors to dissect isoform-unique functions and be developed into drug therapies?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
NADPH Oxidase family of proteins and its regulators, Reactive oxygen/nitrogen species (ROS/RNS), Signal transduction, Cardiovascular disease, Druggable peptidic & small molecules Nox inhibitors

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:

Rigorous high- and low-throughput ROS-detection assays
Biochemical & imaging analysis of protein : protein interaction (e.g., FRET, FRAP, ICS, IVIS)
In vivo models of oxidative stress-driven cardiovascular diseases; generation of new endothelial- and smooth muscle-specific knockout mice
Vessel myography of vascular tone development • Laser Doppler in vivo vascular flow analysis