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Department of Medicine

Department of Medicine

  PhD Community

PhD Community Member



Members:

Elena Goncharova, PhD

Associate Professor, PACCM/VMI
UPMC Montefiore Hospital - NW628
3459 Fifth Avenue
Pittsburgh, PA 15213

Email: eag59@pitt.edu




Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
What are the mechanisms of pulmonary vascular remodeling in Pulmonary Arterial Hypertension (PAH)?

What are the roles of mTOR and HIPPO signaling networks in vascular smooth muscle cell metabolism, proliferation, survival and motility in healthy and diseased pulmonary vasculature?

Can we reverse established pulmonary vascular remodeling and PAH by selectively targeting metabolic, proliferative and pro-survival signaling?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
Pulmonary Arterial Hypertension
Pulmonary vascular remodeling
Vascular smooth muscle cells
Signal transduction
Proliferation, apoptosis, migration, metabolism

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:

Isolation, characterization and functional analysis of human pulmonary vascular cells
Primary human cell-adjusted functional assays (ATP, proliferation, migration, apoptosis)
Immunocytochemistry
Immunohistochemistry
Small animal models of pulmonary hypertension