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Department of Medicine

Department of Medicine

  PhD Community

PhD Community Member



Members:

Zandrea Ambrose, PhD

Assistant Professor, Infectious Diseases
830 Scaife Hall
3550 Terrace Street
Pittsburgh, PA 15261

Email: zaa4@pitt.edu



Conceptual Schematic

THE THREE MOST SIGNIFICANT QUESTIONS THAT DEFINE YOUR RESEARCH PROGRAM:
How does drug resistance influence HIV-1 mucosal transmission and the efficacy of pre-exposure prophylaxis (PrEP)?
How does HIV-1 evolve and persist in host blood and tissues?
What are the mechanisms of HIV-1 capsid uncoating and trafficking to the nucleus and can we exploit them as new therapeutic targets?

FIVE KEYWORDS THAT DESCRIBE YOUR AREAS OF INTEREST:
HIV; Antiretroviral inhibitors; Viral evolution; Reverse transcription; Cell imaging

TECHNIQUES, MODELS, METHODS, ANALYTIC APPROACHES, ETC:

Animal models of HIV/AIDS
Selection of antiretroviral drug resistance
Characterization and inhibition of retroviral/lentiviral life cycle steps
Live-cell and super-resolution imaging of retroviruses/lentiviruses
Single-genome quantitation and sequencing of retroviruses