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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Bin Sun, MD

Research Assistant Professor of Medicine

Email: sunb@upmc.edu

Phone: 412-648-3037

Contact
Office: Starzl Biomedical Science Tower, E1200
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-3037
Fax: 412-648-3046
E-mail: sunb@upmc.edu
Administrative Assistant:
Kristin Mayes
Address: 200 Lothrop Street
BST E1240
Email: kristin.zagenczyk@upmc.edu
Phone: 412-624-3063
Fax: 412-648-5980
Education and Training
Education
MD, Tongji Medical University, Wuhan, China, 1986
MPH, Tongji Medical University, Wuhan, China, 1989
MS, Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX, 1995
Research Interest
Nitric Oxide(NO) is essential in regulating vasodilation. Dr. Gladwin’s lab has discovered nitrite, as NO a reservoir, can be reduced to NO by hemoglobin. Molybdenum(Mo)-containing enzyme mitochondrial amidoxime reducing component 2(mARC2) has also been shown to chemically reduce nitrite to NO under hypoxic condition. I am focusing in establishing cell models by altering mARC2 expression in COS7, endothelial and smooth muscle cells to study the functions and mechanisms of mARC2 as nitrite reductase. The potential of sGC enzyme itself as a nitrite reducatse is under investigation.

The potential role of sGC modulators Bay 41 and Bay 58 compounds in the treatment of sickle cells symptoms by increasing fetal hemoglobin gene expression has been discovered by Gladwin’s lab. The molecular mechanisms and pathways involved in sGC modulators induced fetal hemoglobin gene expression in human primary erythroid progenitor cells will are being explored.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kim, J.J., Yang, L., Lin, B., Zhu, X., Sun, B., Kaplan, A.D., Bett, G.C., Rasmusson, R.L., London, B., Salama, G. Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. Journal of Molecular and Cellular Cardiology. 2015; April 81: 81-93.
Chen, W.C., Baily, J.E., Corselli, M., Diaz, M., Sun, B., Xiang, G., Gray, G.A., Huard. J., Péault, B. Human Myocardial Pericytes: Multipotent Mesodermal Precursors Exhibiting Cardiac Specificity. Stem Cell. 2015; 33(2): 557-73.
Sparacino-Watkins, C.E., Tejero, J., Sun, B., Gauthier, M.C., Thomas, J., Ragireddy, V., Merchant,B.A., Wang, J., Azarov, I., Basu, P., Gladwin, M.T. Nitrite reductase and nitric- mARC2. Journal of Biological Chemistry. 2014; 289(15): 10345-58.
Lavasani, M., Thompson, S.D., Pollett, J.B., Usas, A., Lu, A., Stolz, D.B., Clark, K.A., Sun, B., Péault. B., Huard, J. Human muscle–derived stem/progenitor cells promote functional murine peripheral nerve regeneration. Journal of Clinical Investigation. 2014; 124(4): 1745-1756.
Crisan, M., Casteilla, L., Lehr, L., Carmona, M., Paoloni-Giacobino, A., Yap, S., Sun, B., Léger, B., Logar, A., Pénicaud, L., Schrauwen, P., Cameron-Smith, D., Russell, A.P., Péault, B., Giacobino, J.P. A reservoir of brown adipocyte progenitors in human skeletal muscle. stem cells. 2008; 26(9): 2425-33.
Zheng, B., Cao, B., Crisan, M., Sun, B., Li, G., Logar, A., Yap, S., Pollett, J.B., Drowley, L., Cassino, T., Gharaibeth, B., Deasy, B.M., Huard, J., Peault, B. Prospective identification of myogenic endothelial cells in human skeletal muscle. Nature Biotechnology. 2007; 25(9): 1025-34.
Spiekerkoetter, U., Sun, B., Khuchua, Z., Bennett, M., Strauss, A.W. Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit deficiency. () Human Mutation. Human Mutation. 2003; 21(6): 598-607.
Spiekerkoetter, U,, Sun, B., Zytkovicz, T,, Wanders, R,, Strauss, A., Wendel, U. MS/DS-based newborn and family screening detects asymptomatic patients with very-long-chian acyl-CoA dehydrogenase deficiency. Journal of Pediatrics. 2003; 143(3): 335-42.
Sun, B., Murray, N.R., Fields, A.P. Role for Nuclear Phosphatidylinositol-specific Phospholipase C in the G2/M phase transition. Journal of Biological Chemistry. 1997; 272(42): 26313-17.
Sun, B., Latham, K.A., Dodson, M.L., Lloyd, R.S. Studies on the Catalytic Mechanism of five DNA Glycosylases: probing for Enzyme-DNA Imino Intermediate. . 1995; 270(33): 19501-8.
Sponsored Research/Activities
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Research Assistant
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: Novel Role of Smooth Muscle B5 Reductase in Sickle Cell Disease
Role: Research Assistant
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL133864
Start Year: 2016
End Year: 2020
Title: Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide Hemostasis
Role: Research Assistant
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098032
Start Year: 2013
End Year: 2018