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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Frank C. Sciurba, MD, FCCP

Associate Professor of Medicine

Director, Emphysema Research Center

Director, Pulmonary Function Exercise Physiology Laboratory

Email: sciurbafc@upmc.edu

Phone: 412-648-6494

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-648-6494
Fax: 412-692-4842
E-mail: sciurbafc@upmc.edu
Administrative Assistant:
JoAnne Phillips-Kronz
Email: phillipskronzj@upmc.edu
Phone: 412-648-6494
Fax: 412-692-4842
Education and Training
Education
BS, University of Illinois, 1978
MD, University of Chicago Pritzker School of Medicine, 1982
Training
Intern, Internal Medicine, University of Pittsburgh, 1983
Resident, Internal Medicine, University of Pittsburgh, 1985
Fellowship, Pulmonary and Critical Care, University of Pittsburgh, 1988
Research Interest
Dr. Sciurba's long term research interest includes volume reduction strategies in patients with advanced emphysema and the use of exercise testing as a diagnostic and outcome tool in lung disease.

Among his research interests and published work includes assessment of new concepts related to patterns of pulmonary and systemic inflammation associated with COPD, the impact of therapy on dynamic hyperinflation, the role of quantitative imaging in the assessment and reclassification of COPD, the design of the VENT endobronchial valve trial and role of valves in relieving native lung hyperinflation following lung transplantation, the retinoic acid FORTE trial, gender differences in COPD, assessment of methodology of pulmonary exercise testing and activity monitoring in COPD, and the important role of autoimmunity in the progression of COPD.
Clinical Interest
Dr. Sciurba's clinical focus is on advanced or difficult to manage patients with chronic obstructive pulmonary disease (COPD) including emphysema. Dr. Sciurba, with colleagues at the University of Pittsburgh, have extensive experience in evaluating patients for lung volume reduction surgery. In addition, consideration for enrollment in bronchoscopic volume reduction or other novel, pharmacologic, or biologic clinical trials considered for patients whose options are limited. Dr. Sciurba's clinical and research philosophy revolves around the fact that all patients have a unique manifestation of the disease commonly known as COPD and thus may require a unique therapeutic regimen, specific to their own situation.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Sciurba, FC, Criner, GJ, Strange, C, Shah, PL, Michaud, G, Connolly, Ta, Deslee, G, Tillis, WP, Delage, A, Marquette, CH, Krishna, G, Kalhan, R, Ferguson, JS, Jantz, M, Maldonado, F, Group RSR. Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: The Renew randomized clinical trial. JAMA. 2016; 315(20): 2178-2189.
Sciurba, FC, Chandra, D, Bon, J. Bronchoscopic lung volume reduction in COPD: Lessons in implementing clinically based precision medicine. JAMA. 2016; 315(2): 139-141.
Sciurba, F, Rennard, SI. Rationale for a redundant formulary. The Hawthorne effect and the art of medicine. Am J Respir Crit Care Med. 2015; 191(11): 1224-1225.
Criner, GJ, Connett, JE, Aaron, SD, Albert, RK, Bailey, WC, Casaburi, R, Cooper, JAD Jr, Curtis, JL, Dransfield, MT, Han, MK, Make, B, Marchetti, N, Martinez, FJ, Niewoehner, DE, Scanlon, PD, Sciurba, FC, Scharf, SM, Sin, DD, et al, for the COPD Clinical Research Network and the Canadian Institutes of Health Research. Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med. 2014; 370: 2201-2210.
Bon, J, Liao, S, Tseng, G, Sciurba, FC. Considerations and pitfalls in phenotyping and reclassification of chronic obstructive pulmonary disease. Transl Res. 2013; 162(4): 252-57.
Chandra, D, Wise, RA, Kulkarni, HS, Benzo, RP, Criner, G, Make, B, Slivka, WA, Ries, AL, Reilly, JJ, Martinez, FJ, Sciurba, FC, for the NETT Research Group. Optimizing the six minute walk test as a measure of exercise capacity in COPD. Chest. 2012; 142(6): 1545-52.
Bon, J, Fuhrman, CR, Weissfeld, JL, Duncan, SR, Branch, RA, Chang, CCH, Zhang, Y, Leader, JK, Greenspan, SL, Sciurba, FC. Radiographic emphysema predicts low bone mineral density in a tobacco exposed cohort. Am J Respir Crit Care Med. 2011; 183(7): 885-90.
Sciurba, FC, Ernst, A, Hearth, FJF, Strange, C, Criner, GJ, Marquette, CH, Kovitz, KL, Chiacchierini, RP, Goldin, J, McLennan, G, for the VENT Study Research Group. A randomized study of endobronchial valves for advanced emphysema. N Engl J Med. 2010; 363(13): 1233-44.
Hogg, JC, Chu, F, Utokaparch, S, Woods, R, Elliott, WM, Buzatu, L, Cherniack, RM, Rogers, RM, Sciurba, FC, Coxson, HO, Pare, PD. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Eng J Med. 2004; 350(26): 2645-2653.
Sciurba, FC, Rogers, RM, Keenan, RJ, Slivka, WA, Gorscan, J, Ferson, PF, Holbert, JM, Brown, M, Landreneau, RJ. Improvement in pulmonary function and elastic recoil after lung reduction surgery for diffuse emphysema. N Engl J Med. 1996; 334(17): 1095-1099.
Sponsored Research/Activities
Title: LTRC Clinical Center (Characterization)
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Start Year: 2016
End Year: 2019
Title: LTRC Clinical Center (Core)
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Start Year: 2016
End Year: 2019
Title: Tobacco Phase 12 Formula Funds
Role: Principal Investigator
Funding Agency: Commonwealth of Pennsylvania
Start Year: 2013
End Year: 2016
Title: Lung Tissue Research Consortium (LTRC): Enrollment
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Start Year: 2011
End Year: 2014
Title: Long Term Oxygen Treatment Trial– Core
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: N01 HL76193
Start Year: 2006
End Year: 2016
Title: Systems Level Causal Discovery in Heterogeneous TOPMed Data
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL137159
Start Year: 2017
End Year: 2020
Title: Network Management Core (NEMO) for the Pulmonary Trials Cooperative (PTC)
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL128954
Start Year: 2015
End Year: 2020
Title: Biomarkers Predictive of Lung Function in Decline in Physiologically Normal Smokers
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R21 HL129917
Start Year: 2015
End Year: 2017
Title: Genetic Epidemiology of COPD
Role: Co-Principal Investigator
Funding Agency: National Jewish Health/National Heart, Lung, & Blood Institute
Grant Number: R01 HL089897
Start Year: 2013
End Year: 2017
Title: Genetic Epidemiology of COPD
Role: Co-Principal Investigator
Funding Agency: National Jewish Health/National Institute of Health
Grant Number: U01 HL089897
Start Year: 2007
End Year: 2013
Title: Autoimmunity and Emphysema and Risk of Osteoporosis in Smokers
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL128289
Start Year: 2016
End Year: 2021
Title: Vascular Subphenotypes of Lung Disease (Project 1)
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: CT Assessment of Lung Fissures: Anatomy and Correlated Function
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL096613
Start Year: 2016
End Year: 2019
Title: Four New Ideas to Protect Special Forces from the Stress of High Altitude
Role: Co-Investigator
Funding Agency: University of Colorado
Grant Number: RES W81XWH-15-C-0095
Start Year: 2016
End Year: 2017
Title: Beta-Blockers for the Prevention of Acute Exacerbations of COPD
Role: Co-Investigator
Funding Agency: University of Alabama at Birmingham/Department of Defense
Start Year: 2015
End Year: 2020
Title: A Healthy Literacy Sensitive Decision Aid about Transplantation for COPD Patients
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R21 HL121744
Start Year: 2014
End Year: 2016
Title: Sarcoidosis and A1AT Genomics and Informatics Center
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: U01 HL112707
Start Year: 2012
End Year: 2015
Title: COPD Clinical Research Network - Core
Role: Co-Investigator
Funding Agency: University of Minnesota/National Heart, Lung, & Blood Institute
Grant Number: U10 HL074424
Start Year: 2011
End Year: 2014
Title: COPD Clinical Research Network
Role: Co-Investigator
Funding Agency: University of Minnesota/National Heart, Lung, & Blood Institute
Grant Number: U10 HL074424
Start Year: 2011
End Year: 2014
Title: Longitudinal Follow-up to Genetic Epidemiology of COPD
Role: Co-Investigator
Funding Agency: COPD Foundation
Start Year: 2009
End Year: 2017
Title: SPORE in Lung Cancer Project 2: Vitamin D Modulation of Inflammation and Lung Cancer Risk
Role: Project Co-Leader
Funding Agency: National Cancer Institute
Grant Number: P50 CA090440
Start Year: 2001
End Year: 2016
Notable Achievements
Best Doctors, 2006-2016