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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Jason J Rose, MD, MBA

Assistant Professor of Medicine

Email: rosejj@upmc.edu

Phone: 412-692-2134

Contact
Office: University of Pittsburgh Medical Center, NW 628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2134
Fax: 412-692-2260
E-mail: rosejj@upmc.edu
Administrative Assistant:
Mary Pat Rocco
Email: roccomp@upmc.edu
Phone: 412-624-2735
Fax: 412-383-7113
Education and Training
Education
MBA, Carnegie Mellon University, 2017
MD, Wayne State University School of Medicine, 2010
BSE, Biomedical Engineering, University of Michigan, 2006
Training
Residency, Internal Medicine, Duke University Medical Center, 2013
Fellowship, Pulmonary & Critical Care Medicine, University of Pittsburgh Medical Center, 2016
Postdoctoral Fellowship, University of Pittsburgh, 2017
Research Interest
Dr. Rose's research interests focus on discovering and developing new human therapeutics. His group is working to identify and develop a novel carbon monoxide poisoning antidote. They are also characterizing the mechanisms of severe CO poisoning from a molecular basis and in novel animal models. Dr. Rose's research focuses on studying the mitochondrial effects of carbon monoxide and our ability to reverse the toxicity of carbon monoxide in vitro.
Clinical Interest
Dr. Rose's clinical interests are in the management and care of critically ill patients. He rounds at UPMC Presbyterian, UPMC Montefiore, UPMC East, UPMC McKeesport and the Pittsburgh VA Medical Center. He has a particular interest in critical illness toxicology and inhalational lung disorders.
Educational Interest
Dr. Rose enjoys teaching and training medical students, residents and fellows in their clinical rotations in the Medical Intensive Care Unit.
Publications
Selected Publications:
Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of Therapy. Am J Respir Crit Care Med. 2017; Mar 1; 195(5): 596-606.
Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016; Dec 7;8(368): 368ra173.
Rose JJ, Xu Q, Wang L, Gladwin MT. Shining a Light on Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2015; Nov 15;192(10): 1145-7.
Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Reply: Better Studies Are Needed to Guide Treatment of Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2017; Mar 1;195(5): 694-695.
Rose JJ, Newby LK, Broderick S, Chiswell K, Van de Werf F, Armstrong PW, Mahaffey KW, Harrinton RA, Ohman EM, Giugliano RP, Goodman SG, White HD, Califf RM, Granger CB, Lopes RD. Left Bundle Branch Block in Non-ST-Segment Elevation Acute Coronary Syndromes: Incidence, Angiographic Characteristics, and Clinical Outcomes. J Am Coll Cardiol. 2013; Apr 2;61(13): 1461-3.
Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Reply to Carbon Monoxide Exposure in Workplaces Including Coffee Processing Facilities. Am J Respir Crit Care Med. 2017; May 4.
Rose JJ, Voora D, Cyr DD, Lucas JE, Zaas AK, Woods CW, Newby LK, Kraus WE, Ginsburg GS. Gene Expression Profiles Link Viral Infection, Platelet Function, and Acute Myocardial Infarction. PLoS One. 2015; Jul 20;10(7).
Alvarez RA, Barbash IJ, Rose JJ. Bosentan for sarcoidosis-associated pulmonary hypertension, age-adjusted D-dimer levels in pulmonary embolism, and mean arterial blood pressure targets in septic shock. Am J Respir Crit Care Med. 2014; Oct 15;190(8): 948-9.
Rose Jj, Bealmear B, Nedelkoska L, Studzinski D, Lisak RP, Benjamins JA. Cytokines Decrease Expression of Interleukin-6 Signal Transducer and Leptin Receptor in CNS Glia. J Neurosci Res. 2009; Nov 1;87(14): 3098-106.
Rose JJ, Vanhecke TE, McCullough PA. Clinical Manifestations of Subarachnoid Hemorrhage. Rev Cardiovasc Med. 2010; Fall;11(4): 254-63.
Sponsored Research/Activities
Title: Carbon Monoxide Inhibition of Mitochondrial Function and Efficacy of a Novel Antidotal Therapeutic for Carbon Monoxide Poisoning
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: F32 HL132418
Start Year: 2016
End Year: 2017
Title: Translational Pulmonary Vascular Biology
Role: Post Doctoral Scholar
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: T32 HL110849
Start Year: 2012
End Year: 2017
Notable Achievements
Parker B. Francis Foundation Fellowship, 2017
Robert M. Rogers Award for Outstanding Scholarly Achievement, 2017
Young Investigator Award, AHA, Resuscitation Meeting, 2016
University of Pittsburgh, Department of Medicine, Best Translational Research Fellow, 2015 & 2016
American Thoracic Society Abstract Scholarship, 2013
Robert M. Califf, MD, Medicine Resident Research Award, 2013
Alpha Omega Alpha, 2010
Consortium of Multiple Sclerosis Research Scholarship, 2007
Wayne State University School of Medicine Student Summer Research Fellowship, 2007