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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Mauricio Rojas, MD

Associate Professor of Medicine

Scientific Director, Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease

Email: rojasm@upmc.edu

Phone: 412-624-7225

Contact
Office: Starzl Biomedical Science Tower, W1240
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-624-7225
Fax: 412-624-1670
E-mail: rojasm@upmc.edu
Administrative Assistant:
Terri Heinrich
Email: heinrichta@upmc.edu
Phone: 412-624-7225
Fax: 412-624-1670
Education and Training
Education
BS, Universidad Nacional de Colombia, Bogota, Colombia
MD, Universidad Nacional de Colombia Medical School, Bogota, Colombia
Research Interest
Being trained as a MD doing basic and translational research on immunology, Dr. Rojas has a complete perspective to understand the importance of translational medicine. His basic research is on the biology of lung injury and repair, especially in models of pulmonary fibrosis, acute lung injury and radiation. Dr. Rojas' laboratory has produced pioneer work on the development of pre-clinical models for the use of bone marrow derived-MSC on acute and chronic injury. His novel area of research is the human ex vivo perfusion program, using human normal lungs and diseased lungs, studying the effect of novel therapies like stem cells, non-coding RNAs, small molecules as pre-clinical models for the implementation of new therapies for lung diseases. This protocol in combination of the collection of tissues samples from explanted lungs, has allowed his laboratory to build a program of organ/tissue collection from normal and disease lungs including scleroderma.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Bueno, M, Lai, Y-C, Romero, Y, Brands, J, St. Croix, C, Kamga, C, Corey, C, Herazo-Maya, JD, Sembrat, J, Lee, J, Duncan, SR, Rojas, M, Shiva, S, Chu, CT, Mora, AL. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015; Feb;125(2): 521-38.
Rojas, M, Cardenes, N, Kocyildirim, E, Tedrow, J, Caceres, E, Dean, R, Ting, A, Bermudez, C. Human Adult Bone Marrow-Derived Stem Cells Decrease Severity of LPS-Induced Acute Respiratory Distress Syndrome in Sheep. Stem Cell Res Ther. 2014; Mar 26;5(2): 42.
Bustos, M, Huleihel, L, Kapetanaki, M, Lino-Cardenas, C, Mroz, L, Ellis, B, McVerry, B, Richards, T, Kaminski, N, Cardenes, N, Mora, A, Rojas, M. Aging mensenchymal stem cells fail to protect due to impaired migration and anti-inflammatory response. Am J Respir Crit Care Med. 2014; Apr 1;189(7): 787-98.
Sueblinvong, V, Neujahr, DC, Mills, ST, Roser-Page, S, Ritzenthaler, JD, Guidot, D, Rojas, M, Roman, J. Predisposition for disrepair in the aged lung. Am J Med Sci. 2012; Jul;344(1): 41-51.
Grove, D, Xu, J, Joodi, R, Torres-Gonzales, E, Neujahr, D, Mora, AL, Rojas, M. Attenuation of early airway obstruction by mesenchymal stem cells in a murine model of heterotopic tracheal transplantation. J Heart Lung Transplant. 2011; Mar;30(3): 341-50.
Xu, J, Gonzalez, ET, Iyer, SS, Mac, V, Mora, AL, Sutliff, RL, Reed, S, Brigham, KL, Kelly, P, Rojas, M. Use of Senescence-Accelerate Mouse Model in Bleomycin-Induced Lung Injury Suggests that Bone Marrow-Derived Cells Can Alter the Outcome of Lung Injury in Aged Mice. J Gerontol A Biol Sci Med Sci. 2009; Jul;64(7): 731-9.
Xu, J, Woods, CR, Mora, AL, Joodi, R, Brigham, KL, Iyer, S, Rojas, M. Prevention of Endotoxin-Induced Systemic Response by Bone Marrow- Derived Mesenchymal Stem Cells in Mice. Am J Physiol Lung Cell Mol Physiol. 2007; Jul;293(1): L131-41.
Mora, AL, LaVoy, J, Mckean, M, Stecenko, A, Brigham, KL, Parker, R, Rojas, M. Prevention of NF-kB Activation In vivo by a Cell Permeable NF-kB Inhibitor Peptide. Am J Physiol Lung Cell Mol Physiol. 2005; Oct;289(4): L-536-44.
Rojas, M, Xu, J, Woods, CR, Mora, AL, Spears, W, Roman, J, Brigham, KL. Bone Marrow Derived Mesenchymal Stem Cells in Repair of the Injured Lung. Am J Respir Cell Mol Biol. 2005; Aug;33(2): 145-52.
Rojas, M, Donahue, JP, Tan, Z, Lin, YZ. Genetic engineering of proteins with cell membrane permeability. Nat Biotechnol. 1998; Apr;16(4): 370-5.
Sponsored Research/Activities
Title: Aging of Mesenchymal Stem Cells Missing Link in IPF
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL123766
Start Year: 2015
End Year: 2019
Title: Combination of Extracorporeal Life Support and Mesenchymal Stem Cell Therapy for Treatment of ARDS in Combat Casualties and Evacuation of Service Members with ARDS
Role: Principal Investigator
Funding Agency: Army
Start Year: 2015
End Year: 2017
Title: Pittsburgh Lung Conference 2014
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R13
Start Year: 2014
End Year: 2015
Title: Senescent Stem Cells Increases Susceptibility to Pulmonary Fibrosis
Role: Principal Investigator
Funding Agency: Pulmonary Fibrosis Foundation
Start Year: 2013
End Year: 2015
Title: Cell Therapy for the Treatment of Acute Respiratory Distress Syndrome
Role: Co-Principal Investigator
Funding Agency: Athersys, Inc./National Institute of Allergy & Infectious Diseases
Grant Number: R42 AA024003
Start Year: 2015
End Year: 2016
Title: F box-Induced Acute Lung Injury and Parkin
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL096376
Start Year: 2016
End Year: 2020
Title: RV/PA Recoupling by Bone Marrow Derived Mesenchymal Stem Cells
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL114795
Start Year: 2012
End Year: 2017
Title: Development of Anti-CXCR4 Compounds to Block Breast Cancer Metastasis
Role: Co-Investigator
Funding Agency: Emory University/National Cancer Institute
Grant Number: R01 CA162306
Start Year: 2012
End Year: 2017
Notable Achievements
he Dozer Visiting Professor Award. Ben-Gurion University, Be’ersheva, Israel, 2016
Honors Recognition University of Pittsburgh, 2015
PACCM Faculty Translational Scholar Award. University of Pittsburgh, 2014
Established Investigator Award Pulmonary Fibrosis Foundation, 2013
ATS Assembly on Respiratory Cell and Molecular Biology Carol Basbaum Award, 2014
Travel Award – European Respiratory Society Conference 2012 Estoril, Portugal, 2012
Travel Award – Society of Critical Care Medicine 41st Congress, 2012
Honors Recognition University of Pittsburgh, 2012
Respiratory Cell & Molecular Biology Service Award, American Thoracic Society, International Conference, Denver, Colorado, 2011
McGowan Institute of Regenerative Medicine Research Award, 2011