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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Janet So-Jung Lee, MD

Professor of Medicine

T1 Translational Track Director, Institute for Clinical Research Education

Member, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute

Email: leejs3@upmc.edu

Phone: 412-692-2211

Contact
Office: UPMC Montefiore Hospital, NW628
3459 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-692-2211
Fax: 412-692-2260
E-mail: leejs3@upmc.edu
Administrative Assistant:
Shannon McKenzie
Email: mckenziesj@upmc.edu
Phone: 412-692-2211
Fax: 412-692-2260
Education and Training
Education
BA, The Johns Hopkins University, 1991
MD, Georgetown University, 1995
Medicine Internship, University of Alabama at Birmingham, 1996
Medicine Residency, University of Alabama at Birmingham, 1998
Training
Pulmonary & Critical Care Fellowship, University of Washington, 2001
Post Doctoral Fellowship, University of Washington, 2004
Research Interest
Broadly speaking, our laboratory studies the biology of critical illness and host determinants of lung injury. Our research focuses upon the innate arm of immunity, specifically examining how phagocytes such as macrophages and neutrophils recognize and respond to exogenous pathogen associated molecular patterns (PAMPs) or endogenous alarmins. We are interested in probing host-pathogen interactions to examine mechanisms of host protection following pathogen-triggered injury from products of extracellular gram negative pathogens such as Pseudomonas aeruginosa and Klebsiella pneumoniae. We are also interested in the factors that shape repair and resolution following injury, specifically factors derived from hematopoietic cells such as platelets and red blood cells that can influence the course of inflammation. We utilize a repertoire of relevant murine models of injury, molecular genetic approaches, in vitro biochemical assays, and human bio-samples to examine innate host defenses of the lung.
Clinical Interest
Dr. Lee’s clinical interest and focus is acute lung injury, acute and chronic respiratory failure, transfusion consequences in the critically ill, sepsis-related immunosuppression, and other critical illness syndromes. Her clinical service is focused in the Medical Intensive Care Unit and the Advanced Lung Disease Service of the University Hospital.
Educational Interest
Dr. Lee is actively involved in research training and teaching of medical students, graduate students, residents and fellows in Pulmonary and Critical Care Medicine. Her educational interest primarily focuses on training the next generation of physician-scientists and scientists interested in innate immunity, inflammation, cellular and molecular pathology of the lung.
Publications
For my complete bibliography, Click Here.
Selected Publications:
McComb JG, Ranganathan M, Pilewski JM, Ray P, Watkins SC, Choi AM, Lee JS. CX3CL1 Upregulation is Associated with Recruitment of CX3CR1+ Mononuclear Phagocytes and T Lymphocytes in the Lungs during Cigarette Smoke Induced Emphysema. The American Journal of Pathology. 2008; October 173(4): 949-61.
Mangalmurti NS, Xiong Z, Hulver M, Ranganathan M, Liu XH, Oriss T, Rubin M, Triulzi D, Choi A, Lee JS. Loss of Red cell Chemokine Scavenging Promotes Transfusion Related Lung Inflammation. Blood. 2009; January 29; 113(5): 1158-66.
Mangalmurti NS, Chatterjee S, Chen GJ, Mohammed A, Anderson E, Siegel DL, Schmidt AM, Albelda SM, Lee JS. Advanced glycation endproducts on stored erythrocytes increase endothelial reactive oxygen species generation through interaction with RAGE. Transfusion. 2010; November; 50(11):.
Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity. 2010; July 23;33(1): 106-17.
Lee JS, Gladwin MT. Bad Blood: The Risks of Red Cell Storage. Bedside to Bench Invited Commentary. Nature Medicine. 2010; 16: 381–382.
Xiong Z, Cavaretta J, Qu L, Stolz DB, Triulzi D, Lee JS. Red cell microparticles show altered inflammatory chemokine binding and release ligand upon interaction with platelets. Transfusion. 2010; 51(3): 610-621.
Xiong Z, Leme AS, Ray P, Shapiro SD, Lee JS. CX3CR1+ Lung Mononuclear Phagocytes Spatially Confined to the Interstitium Produce TNF-Alpha and IL-6 and Promote Cigarette Smoke Induced-Emphysema. The Journal of Immunology. 2011; March 1;186(5): 3206-14.
Zhao Y, Xiong Z, Lechner EJ, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS. Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury. Mucosal Immunol. 2014; March;7(2): 440-8.
Zhao Y, Olonisakin TF, Xiong Z, Hulver M, Sayeed S, Yu MT, Gregory AD, Kochman EJ, Chen BB, Mallampalli RK, Sun M, Silverstein RL, Stolz DB, Shapiro SD, Ray A, Ray P, Lee JS. Thrombospondin-1 regulates neutrophil microbial killing by restraining granule serine proteases during K. pneumoniae infection. Mucosal Immunol. 2014; December 10; 8(4): 896-905.
Balasubramanian KK, Maeda A, Lee JS, Mohammadyani D, Tyurin VA, Tyurina YY, Ray P, Klein-Seetharaman J, Mallampalli RK, Bayir H, Fadeel B, Kagan VE. Extracellular Cardiolipins Are Phagocytized by Macrophages and Silence LPS Signaling by Mimicking Immature Lipid A. Science Signal. 2015; September 22;8(395):.
Sponsored Research/Activities
Title: Enhancing Neutrophil Responses to Counter MDR Gram Negative Bacterial Pneumonia
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI119042
Start Year: 2015
End Year: 2017
Title: Red Cell Transfusion: Modifier of Lung and Systemic Inflammatory Responses
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL086844
Start Year: 2013
End Year: 2018
Title: Immunophenotyping Lung Mononuclear Phagocytes in Chronic Obstructive Pulmonary Disease
Role: Principal Investigator
Funding Agency: Healthy Lungs Pennsylvania
Start Year: 2012
End Year: 2016
Title: CX3CR1 and Lung Inflammation by Second Hand Smoke
Role: Principal Investigator
Funding Agency: Flight Attendants Medical Research Institute
Start Year: 2012
End Year: 2015
Title: Duffy Antigen: Modifier of Systemic and Lung Chemokine Responses in Inflammation
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL086884
Start Year: 2007
End Year: 2013
Title: Regulation of Neutrophilic Inflammation in Cystic Fibrosis
Role: Co-Investigator
Funding Agency: Cystic Fibrosis Foundation
Start Year: 2015
End Year: 2019
Title: Cardiolipin as a Novel Mediator of Acute Lung Injury - Project 3
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL114453
Start Year: 2014
End Year: 2018
Title: Hemostasis and Vascular Biology Research Institute-Lee
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Grant Number: RES
Start Year: 2013
End Year: 2028
Title: Storage Lesion in Banked Blood due to Disruption of Nitric Oxide Hemostasis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098032
Start Year: 2013
End Year: 2018
Notable Achievements
Outstanding Senior Resident, William E. Dismukes Award of Excellence, University of Alabama at Birmingham, 1998
Elected Member, American Society for Clinical Investigation, 2013
Member, American Thoracic Society Research Advocacy Committee, 2011-2016
Faculty Member, Cellular and Molecular Pathology Graduate Training Program, University of Pittsburgh, 2014
Member, Steering Committee MSTP Training, University of Pittsburgh, 2014
Vice Chair, American Thoracic Society Membership Committee, 2015
PACCM Outstanding Mentor Award, University of Pittsburgh, 2015
Permanent Member, NIH Standing Study Section, Innate Immunity and Inflammation, 2015-2019
Director, Pulmonary Translational Research Core, Division of Pulmonary, Allergy, Critical Care Medicine, 2016
Member, American Thoracic Society Finance Committee, 2016