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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Yen-Chun Charly Lai, PhD

Research Assistant Professor of Medicine

Email: yel19@pitt.edu

Phone: 412-648-3037

Contact
Office: Starzl Biomedical Science Tower, E1200
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-3037
Fax:
E-mail: yel19@pitt.edu
Administrative Assistant:
Carla Monzo
Email: monzocm@upmc.edu
Phone: 412-383-5853
Fax: 412-648-5980
Education and Training
Education
PhD, Biological Chemistry, National Defense Medical Center/Academia Sinica, 2011
Training
Postdoctoral Fellow, Vascular Medicine Institute, University of Pittsburgh, 2015
Research Interest
Dr. Lai's research has been focused primarily on exploring new pathogenesis and developing alternative therapies for effective treatment of cardiopulmonary diseases, with the particular emphasis of metabolic syndrome, pulmonary hypertension, and heart failure with preserved ejection fraction (PH-HFpEF). Most recently, much of her interests and efforts have been focused on unraveling the role of SIRT3 in skeletal muscle and its mediation of endocrine signaling pathways in PH-HFpEF.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Lai, YC, Tabima, DM, Dube, JJ, Hughan, KS, Vanderpool, RR, Goncharov, DA, St. Croix, CM, Garcia-Ocana, A, Goncharova, EA, Tofovic, SP, Mora, AL, Gladwin, MT. SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Circulation. 2016; 133(8): 717-31.
Hu, J, Xu, Q, McTiernan, C, Lai, YC, Osei-Hwedieh, D, Gladwin, M. Novel Targets of Drug Treatment for Pulmonary Hypertension. American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions. 2015; 15(4): 225-34.
Bueno, M, Lai, YC, Romero, Y, Brands, J, St. Croix, CM, Kamga, C, Corey, C, Herazo-Maya, JD, Sembrat, J, Lee, JS, Duncan, SR, Rojas, M, Shiva, S, Chu, CT, Mora, AL. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. The Journal of Clinical Investigation. 2015; 125(2): 521-38.
Lai, YC, Potoka, KC, Champion, HC, Mora, AL, Gladwin, MT. Pulmonary arterial hypertension: the clinical syndrome. Circulation Research. 2014; 115(1): 115-30.
Zhu, X, Ng, HP, Lai, YC, Craigo, JK, Nagilla, PS, Raghani, P, Nagarajan, S. Scavenger receptor function of mouse Fc? receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice. Journal of immunology. 2014; 193(5): 2483-95.
Sparacino-Watkins, CE, Lai, YC, Gladwin, MT. Nitrate-nitrite-nitric oxide pathway in pulmonary arterial hypertension therapeutics. Circulation. 2012; 125(23): 2824-6.
Lai, YC, Pan, KT, Chang, GF, Hsu, CH, Khoo, KH, Hung, CH, Jiang, YJ, Ho, FM, Meng, TC. Nitrite-mediated S-nitrosylation of caspase-3 prevents hypoxia-induced endothelial barrier dysfunction. Circulation Research. 2011; 109(12): 1375-86.
Sponsored Research/Activities
Title: Role of Skeletal Muscle SIRT3 in Modulating Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)
Role: Principal Investigator
Funding Agency: American Heart Association-Great Rivers
Grant Number: RES
Start Year: 2017
End Year: 2019
Title: Effect of Remodulin in Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction (PH-HFpEF)
Role: Principal Investigator
Funding Agency: United Therapeutics Corp.
Grant Number: RES
Start Year: 2016
End Year: 2019
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: Use of SGC Activators to Bypass NO Scavenging in SCD
Role: Co-Investigator
Funding Agency: Bayer Corporation
Start Year: 2014
End Year: 2016
Title: Vascular Subphenotypes of Lung Disease - Core A
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016