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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Tamir Kanias, PhD

Assistant Professor of Medicine

Email: tak77@pitt.edu

Phone: 412-624-5004

Contact
Office: Starzl Biomedical Science Tower, E1200-22B
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-624-5004
Fax: 412-648-5980
E-mail: tak77@pitt.edu
Administrative Assistant:
Carla Monzo
Email: monzocm@upmc.edu
Phone: 412-383-5853
Fax: 412-648-5980
Education and Training
Education
BS, Biological Sciences, Tel Aviv University, Israel, 1998
MS, Agricultural Sciences, Hebrew University, Israel, 2002
PhD, Medical Sciences, University of Alberta, Canada, 2010
Training
Post-doctoral Fellow, Vascular Medicine, University of Pittsburgh, 2013
Research Interest
RED Blood Cell physiology and Pathology
• The red blood cell storage lesion
• Molecular and genetic determinates of hemolysis
• Donor genetic variability including gender in stored red blood cells
• Role of sex hormones, particularly androgens, in modulating hemolysis during storage and after transfusion
• Characterization of canonical transient receptor potential (TRPC) cation channels and voltage-gated calcium
channels in human and mouse red cells
• Development of new therapeutics for red cell storage and transfusion using steroid and non steroid TRPC
blockers
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kanias T, Sinchar D, Osei-Hwedieh D, Baust JJ, Jordan A, Zimring JC, Waterman HR, Acker JP, Gladwin MT. Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress and disease. Transfusion. 2016; Accepted manuscript.
Risbano MG, Kanias T, Triulzi D, Donadee C, Barge S, Badlam J, Jain S, Belanger AM, Kim-Shapiro DB, Gladwin MT. Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function. American journal of respiratory and critical care medicine. 2015; 192(10): 1223-33.
Kanias T, Wang L, Lippert A, Kim-Shapiro DB, Gladwin MT. Red blood cell endothelial nitric oxide synthase does not modulate red blood cell storage hemolysis. Transfusion. 2013; 53(5): 981-9.
Kanias T, Gladwin MT. Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient. Transfusion. 2012; 52(7): 1388-92.
Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT. Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation. 2011; 124(4): 465-76.
Kanias T, Acker JP. Mechanism of hemoglobin-induced cellular injury in desiccated red blood cells. Free Radical Biology and Medicine. 2010; 49(4): 539-47.
Kanias T, Acker JP. Biopreservation of red blood cells--the struggle with hemoglobin oxidation. FEBS Journal. 2010; 277(2): 343-56.
Huang S, Hou HW, Kanias T, Sertorio JT, Chen H, Sinchar D, Gladwin MT, Han J. Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage. Lab on a chip. 2015; 15(2): 448-58.
Jordan A, Chen D, Yi QL, Kanias T, Gladwin MT, Acker JP. Assessing the influence of component processing and donor characteristics on quality of red cell concentrates using quality control data. Vox Sanguines. 2016; Online First Ahead of Print.
Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda JA, Gladwin MT, Singh AK, Gordeuk VR. Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy. Haematologica. 2015; 100(10): 1275-84.
Sponsored Research/Activities
Title: Genetic Basis of Differential Blood Donor RBC Storage Capacity/Polymorphisms that Improve Hemoglobin and/or Storage Iron in High Intensity Blood Donors
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Start Year: 2015
End Year: 2016
Title: Storage Lesion in Banked Blood Due to Disruption of Nitric Oxide Hemostasis
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL098032
Start Year: 2013
End Year: 2018
Title: Vascular Subphenotypes of Lung Disease - Project 3
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016
Title: Vascular Subphenotypes of Lung Disease - Core A
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016