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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Jeffrey S. Isenberg, MD, MPH

Associate Professor of Medicine

Email: jsi5@pitt.edu

Phone: 412-383-5853

Contact
Office: Starzl Biomedical Science Tower, E1258
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-383-5853
Fax: 412-648-5980
E-mail: jsi5@pitt.edu
Administrative Assistant:
Carla Monzo
Email: monzocm@upmc.edu
Phone: 412-383-5853
Fax: 412-648-5980
Education and Training
Education
BA, University of Pennsylvania, 1982
Masters of Public Health, Tulane University School of Public Health, 1985
MD, Tulane University School of Medicine, 1986
Training
General Surgery Internship, St. Luke’s – Roosevelt Medical Center, 1987
General Surgery, Staten Island University Hospital, 1992
Plastic and Reconstructive Surgery, Yale University School of Medicine, 1994
Hand Surgery, Combined Program in Surgery of the Hand, University of Connecticut, 1994
Microsurgery, University of Southern California, 1995
Research Interest
Dr. Isenberg's research interests have centered on the need to enhance tissue blood flow, perfusion and wound healing, and stem from his background as a reconstructive microsurgeon. As a clinician, the focus of his work was the development and application of novel autologous composite tissue units for closure of complex wounds. In addition to anatomical research in tissue vascular anatomy, he studied the ability of complex tissue reconstructive units to withstand stress injuries. This enabled him to improve the clinical range of these surgical approaches. However, limitations with clinical results achievable via surgical interventions alone motivated him to focus purely on research. He now studies the molecular aspect of blood flow and perfusion, and has recently discovered a novel inhibitory pathway that blocks physiologic nitric oxide (NO) signaling.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Rogers, N.M., Seeger, F., Garcin, E.D., Roberts, D.D., Isenberg, J.S. Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow. Front Physiol. 2014; 5: 134.
Rogers, N.M., Thomson, A.W., Isenberg, J.S. Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury. J Am Soc Nephrol. 2012; 23: 1538.
Bauer, P.M., Bauer, E.M., Rogers, N. M., Yao, M., Feijoo-Cuaresma, M., Pilewski, J.M., Champion, H.C., Zukerbraun, B.S., Calzada, M.J., Isenberg, J.S. Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc Res. 2012; 93: 682.
Sponsored Research/Activities
Title: Regulators of Ischemic Fracture Healing
Role: Co-Investigator
Funding Agency: Michigan State University/National Institute of Arthristis, Muscoskel, & Skin Disease
Grant Number: R01 AR066028
Start Year: 2015
End Year: 2020
Title: Immunoregulatory Mechanisms of IL-33 in Heart Transplantation
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL122489
Start Year: 2015
End Year: 2020
Title: University of Pittsburgh Undergraduate Student Research Program
Role: Principal Investigator
Funding Agency: American Heart Association-National
Start Year: 2015
End Year: 2017
Title: Augmentation of CD47 Signaling in Aging Exacerbates Cardiovascular Disease
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL112914
Start Year: 2015
End Year: 2017
Title: Bioengineering Tracheas through Targeting Activated CD47
Role: Co-Principal Investigator
Funding Agency: National Institute of Biomedical Imaging and Bioengineering
Grant Number: R21 EB017184
Start Year: 2014
End Year: 2017
Title: Investigations into the Molecular Pathways by which Decellularized Matrix Regulates Wound Healing
Role: Principal Investigator
Funding Agency: ACell, Inc.
Start Year: 2014
End Year: 2016
Title: Pittsburgh Center for Kidney Research - Pilot
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2013
End Year: 2018
Title: TSP-1 ROS: CD47 and SIRP-alpha as Mediators of Vascular Dysfunction
Role: Co-Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL112914
Start Year: 2013
End Year: 2017
Title: Biodegradable Synthetic Vascular Graft
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL089658
Start Year: 2012
End Year: 2017
Title: Pittsburgh Center for Kidney Research
Role: Co-Investigator
Funding Agency: National Institute of Diabetes, Digestive, & Kidney Disease
Grant Number: P30 DK079307
Start Year: 2012
End Year: 2013
Title: Vascular Subphenotypes of Lung Disease - Project 3
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2011
End Year: 2016
Title: TSPI-CD47 in Promotion of PAH-Associated Vasoconstriction and Vascular Overgrowth
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL108954
Start Year: 2011
End Year: 2016
Title: Hemostasis and Vascular Biology Research Institute - Project 2 Isenberg
Role: Co-Investigator
Funding Agency: Hemophilia Center of Western PA
Start Year: 2008
End Year: 2018