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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Elena A. Goncharova, PhD

Associate Professor of Medicine

Email: eag59@pitt.edu

Phone: 412-648-8474

Contact
Office: Starzl Biomedical Science Tower, Rm 1259
200 Lothrop Street
Pittsburgh, PA 15261
 
Phone: 412-648-8474
Fax: 412-648-3046
E-mail: eag59@pitt.edu
Administrative Assistant:
Carla Monzo
Address: 200 Lothrop St. | BST E1240 |
Pittsburgh, PA 15261
Phone: 412-648-3181
Fax: 412-648-5980
Education and Training
Education
MS, Biochemistry, Moscow Lomonosov State University, 1993
PhD, Biology, Cardiology Research Center, Russian Academy of Sciences, 2000
Training
Post-doctoral Researcher, signal transduction, University of Pennsylvania School of Medicine, 2005
Research Interest
Dr. Goncharova’s research interests have focused on the molecular and cellular mechanisms regulating metabolism, proliferation, motility and survival of smooth muscle cells as it relates to the pathogenesis of pulmonary arterial hypertension (PAH) and pulmonary lymphangioleiomyomatosis (LAM). Her current work specifically focuses on the roles of mammalian target of rapamycin (mTOR)and HIPPO signaling networks as a master-regulators of VSM remodeling in PAH. Dr. Goncharova's lab uses human-derived tissues and cells, genetically modified mice and rodent animal models of PH to dissect new signaling events driving PAH pathogenesis, identify and test new molecular targets. Dr. Goncharova's lab also runs VMI Cell Processing Core (isolates, characterizes and biobanks pulmonary vascular cells from subjects with PAH and donor lungs) and Animal Hypoxic Core (provides the platform and technical support for hypoxia-based modeling of PH in rodents).
Educational Interest
2003-present
Mentoring of pre- and post-doctoral students, research fellows and junior faculties

2015-present
Graduate Faculty, University of Pittsburgh Cellular & Molecular Pathology Graduate Program

2015-present
Faculty, University of Pittsburgh Institute for Clinical Research Education

2015
Facilitator, pharmacology conference (GPCR drugs), Cellular and Pathologic Basis of Disease/Pharmacology course

2016-present
Small group leader, CLRES 2071 Research Design and Development seminar, Degree Granting Programs in Clinical Research, Grant Writing Course

2016
Lecturer, Principles of Pharmacology course

2016
Faculty mentor, First Experiences in Research Program
Publications
For my complete bibliography, Click Here.
Selected Publications:
Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HHW, Shapiro S, Zhao Y, Goncharova EA. HIPPO-integrin linked kinase crosstalk controls self-sustaining proliferation and survival in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 2016; Epub ahead of print.
Lai YC, Tabima DM, Dube JJ, Hughan KS, Vanderpool RR, Goncharov DA, St Croix CM, Garcia-Ocaña A, Goncharova EA, Tofovic SP, Mora AL, Gladwin MT. SIRT3-AMPK activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension in heart failure with preserved ejection fraction (PH-HFpEF). Circulation. 2016; 133(8): 717-731.
Kudryashova TV, Goncharov DA, Pena A, Ihida-Stansbury K, DeLisser H, Kawut SM, Goncharova EA. Profiling the role of mTOR in the vascular smooth muscle metabolome in pulmonary arterial hypertension. Pulmonary Circulation. 2015; 5(4): 667-680.
Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong S-B, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt L, Krymskaya VP. Folliculin controls lung alveolar enlargement and epiteliak cell survival through E-cadherin, LKB1, and AMPK. Cell Reports. 2014; 7(2): 412-423.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension. Circulation. 2014; 129(8): 864-874.
Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP. Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Science Translational Medicine. 2012; 4(154): 154ra134.
Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA. mTOR is Required for Pulmonary Arterial Vascular Smooth Muscle Cell Proliferation Under Chronic Hypoxia. The FASEB Journal. 2011; 25(6): 1922-1933.
Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP. mTORC2 is Required for Proliferation and Survival of TSC2-Null Cells. Molecular and Cellular Biology. 2011; 31(12): 2484-2498.
Goncharova E, Goncharov D, Noonan D, Krymskaya VP. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. Journal of Cell Biology. 2004; 167(6): 1171-1182.
Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri RA, Krymskaya VP. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). Journal of Biological Chemistry. 2002; 277(34): 30958-30967.
Sponsored Research/Activities
Title: HIPPO Signaling in Pulmonary Arterial Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL130261
Start Year: 2016
End Year: 2020
Title: Evaluation of the Role of Gremlin 1, Activin A and PDGFRB in Pulmonary Hypertension
Role: Principal Investigator
Funding Agency: Regeneron Pharmaceuticals, Inc.
Grant Number: RES
Start Year: 2016
End Year: 2018
Title: mTOR Coordinates Cell Metabolism, Growth and Survival in Pulmonary Hypertension
Role: Principal Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R01 HL113178
Start Year: 2013
End Year: 2017
Title: Therapeutic Targeting of Vascular Subphenotypes of Lung Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: P01 HL103455
Start Year: 2016
End Year: 2021
Title: Hemostasis and Vascular Biology Research Institute - Cell Processing Core-Goncharova
Role: Co-Investigator
Funding Agency: Hemophilia Center of Western PA
Start Year: 2013
End Year: 2028
Title: Hemostasis and Vascular Biology Research Institute-Goncharova
Role: Co-Investigator
Funding Agency: Institute for Transfusion Medicine
Start Year: 2013
End Year: 2028
Title: University of Pittsburgh Clinical and Translational Science Institute - Research Education Core
Role: Co-Investigator
Funding Agency: National Center for Advancing Translational Sciences
Grant Number: UL1 TR000005
Start Year: 2011
End Year: 2016
Notable Achievements
Reviewer, NIH/NHLBI ZRG1 CVRS G (02) M Pulmonary Diseases, 2014-2016
Scientist reviewer, Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP), 2011-2016
University of Pittsburgh VMI-HVI Innovator Award, 2014
LAM Foundation Francis G. Byrnes Conference Award, 2013
Penn Department of Medicine Robert Austrian Award in Bench Research, 2012
American Lung Association Biomedical Research Award, 2011
Gilead Sciences Research Scholars Award in Pulmonary Arterial Hypertension, 2010
ATS/LAM Foundation Research Award, 2008
Parker B. Francis Fellowship Award, 2008
LAM Foundation Fellowship Award, 2005