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Department of Medicine

Department of Medicine

  Division of Pulmonary, Allergy and Critical Care Medicine



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photo Samit Ghosh, PhD

Research Assistant Professor of Medicine

Email: sag130@pitt.edu

Phone: 412-648-9427

Contact
Office: E1200-8B Biomedical Science Tower (BST)
200 Lothrop St
Pittsburgh, PA 15261
 
Phone: 412-648-9427
Fax: 412-648-5980
E-mail: sag130@pitt.edu
Administrative Assistant:
Kathy Brickett
Email: brickettk@upmc.edu
Phone: 412-624-3239
Fax: 412-648-5980
Education and Training
Education
PhD, Chittaranjan National Cancer Institute, Jadavpur University, India, 2005
MSc, University of Burdwan, India, 1999
Training
Postdoctoral Fellowship, Emory University, Atlanta, GA, 2008
Postdoctoral Associate, University of Texas Health Science Center at Tyler, TX, 2005
Research Interest
Dr. Ghosh’s research goal is to delineate a translational pathway and to design platforms to expedite repair and regenerative therapeutics for the treatment of pulmonary complications of sickle cell disease (SCD). He investigates the underlying mechanisms that lead to acute or chronic pulmonary complications of SCD. His research involves two major components of SCD. One is to determine the role of TLR4 signaling and vascular adhesion machinery in the development of Acute Chest Syndrome in SCD. The other component is to define Nrf2 regulated redox mechanisms that can be targeted therapeutically to prevent chronic disease progression leading to end organ damage in SCD. His research could provide a solid foundation identifying precision drugs for protection and/or attenuation of acute and chronic lung complications in SCD. In addition, his studies offer the potential of identifying the sub-group of SCD patients at higher risk of end-organ damage, who will be more suitable for high-risk experimental therapy.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Charrin E, Dubé JJ, Connes P, Pialoux V, Ghosh S, Faes C, Ofori-Acquah SF, Martin C. Moderate exercise training decreases inflammation in transgenic sickle cell mice. Blood Cells, Molecules and Diseases. 2017.
Ghosh S, Ihunnah CA, Hazra R, Walker AL, Hansen JM, Archer DR, Owusu-Ansah AT, Ofori-Acquah SF. Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice. JCI Insight. 2016; 1(4).
Tan F, Ghosh S, Mosunjac M, Manci E, Ofori-Acquah SF. Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model. Experimental Biology and Medicine. 2016; 241(7): 766-771.
Green M, Akinsami I, Lin A, Banton S, Ghosh S, Chen B, Platt M, Osunkwo I, Ofori-Acquah S, Guldberg R, Barabino G. Microarchitectural and mechanical characterization of the sickle bone. Journal of the Mechanical Behavior of Biomedical Materials. 2015; 48: 220-228.
Manci EA, Hyacinth HI, Capers PL, Archer DR, Pitts S, Ghosh S, Patrickson J, Titford ME, Ofori-Acquah SF, Hibbert JM. High protein diet attenuates histopathologic organ damage and vascular leakage in transgenic murine model of sickle cell anemia. Experimental Biology and Medicine. 2014; 239(8): 966-974.
Ghosh S, Adisa OA, Chappa P, Tan F, Jackson KA, Archer DR, Ofori-Acquah SF. Extracellular hemin crisis triggers acute chest syndrome in sickle mice. Journal of Clinical Investigation. 2013; 123(11): 4809-4820.
Adisa OA, Hu Y, Ghosh S, Aryee D, Osunkwo I, Ofori-Acquah SF. Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease. British Journal of Haematology. 2013; 162(5): 702-705.
Ghosh S, Tan F, Ofori-Acquah SF. Spatiotemporal dysfunction of the vascular permeability barrier in transgenic mice with sickle cell disease. Anemia. 2012; 2012: 582018.
Hendrickson JE, Hod EA, Perry JR, Ghosh S, Chappa P, Adisa O, Kean LS, Ofori-Acquah SF, Archer DR, Spitalnik SL, Zimring JC. Alloimmunization to transfused HOD red blood cells is not increased in mice with sickle cell disease. Transfusion. 2012; 52(2): 231-240.
Ghosh S, Tan F, Yu T, Li Y, Adisa O, Mosunjac M, Ofori-Acquah SF. Global gene expression profiling of endothelium exposed to heme reveals an organ-specific induction of cytoprotective enzymes in sickle cell disease. PLoS One. 2011; 6(3): e18399.