Department of Medicine
University of Pittsburgh
Carol Feghali-Bostwick, PhD
 |
Assistant Professor of Medicine Phone: 412 692 2214
|
Bio
Dr. Feghali-Bostwick is a graduate of the American University of Beirut, receiving both her bachelor’s and master’s degrees, and Tulane University, where she received her Ph.D. in Microbiology and Immunology. She completed post-graduate fellowship training in the Division of Rheumatology and Clinical Immunology at the University of Pittsburgh.
Academic and Research Interests
Dr. Feghali-Bostwick’s laboratory focuses on identifying the role of insulin-like growth factor binding proteins in aberrant extracellular matrix production in Systemic Sclerosis (Scleroderma) and Idiopathic Pulmonary Fibrosis, in the development of dermal and pulmonary fibrosis. Current members of the laboratory are exploring mechanisms mediating the development, progression, and perpetuation of fibrosis. Dr. Feghali-Bostwick is also conducting a study on twins with Scleroderma to delineate the role of environmental and genetic factors in the development of the disease.
Key Publications
E Hsu and Feghali-Bostwick CA. Insulin-Like Growth Factor-II Is Increased in Systemic Sclerosis-Associated Pulmonary Fibrosis and Contributes to the Fibrotic Process via Jun N-Terminal Kinase- and Phosphatidylinositol-3 Kinase-Dependent Pathways. American Journal of Pathology. 2008;172:1580-1590
H Yasuoka, Zhou Z, Pilewski JM, Oury TD, Choi AMK and Feghali-Bostwick CA. Insulin-Like Growth Factor-Binding Protein-5 Induces Pulmonary Fibrosis and Triggers Mononuclear Cellular Infiltration. American Journal of Pathology. 2006;169:1633-1642
Feghali-Bostwick C, Medsger TA Jr, Wright TM. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum. 2003 Jul;48(7):1956-63.
PubMed Link
News
Dr. Feghali-Bostwick is featured in the newsletter of the Scleroderma Foundation here and here. She serves on the Board of Directors for this Foundation