Department of Medicine
University of Pittsburgh
Jessica M. Bon, MD
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Assistant Professor of Medicine Phone: 412-648-6494 |
Bio
Jessica Bon received her MD from Jefferson Medical College in Philadelphia, Pennsylvania. She completed her residency in internal medicine and a year as chief medical resident at Thomas Jefferson University Hospital in Philadelphia. After residency, she completed her fellowship training in pulmonary and critical care medicine at the University of Pittsburgh. She joined the faculty in the Division of Pulmonary, Allergy and Critical Care Medicine at the University of Pittsburgh in July of 2008.
Clinical Interests
Dr. Bon’s clinical interests are focused on the management and treatment of chronic obstructive pulmonary disease (COPD). In her outpatient pulmonary practice, she evaluates patients for lung volume reduction surgery and manages patients with difficult to treat and severe COPD.
Academic and Research Interests
Dr. Bon’s academic and research interests focus on the study of phenotypic heterogeneity in COPD. She is particularly interested in the systemic manifestations of COPD and their relationship to anatomic, physiologic, functional, and molecular disease expression.
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Scatterplot of the fraction of quantitative computed tomography (CT) voxels with tissue attenuation values less than -950 Hounsefield units (F-950), a measure of emphysema, versus the right upper apical lobe bronchus wall area as a percentage of total airway area (WA%), a surrogate for small airway thickening. Tertiles of F-950 and WA% are demarcated by the dotted horizontal and vertical lines within the scatterplot with the mean forced expiratory volume in 1 second (FEV1) percent predicted values represented in the corresponding color-coded grid. No association exists between F-950 and WA% (r = -0.055, p = 0.40) and the severity of parenchymal emphysema and airway disease cannot be predicted based on FEV1 alone. |
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Electron microscopy of normal lung and a lung with emphysematous changes (upper left and upper right figures) and normal bone and bone with osteoporotic changes (lower left and lower right figures). An association between COPD and osteoporosis has been established but the precise mechanisms underlying the relationship of these two disease processes is not known. |
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Plot of the forced expiratory volume in one second (FEV1) percent predicted versus the ratio of FEV1 to forced vital capacity (FVC) for a combined screening and COPD population (n=4,504). Ninety percent prediction intervals are indicated for GOLD II, III, and IV distribution. Of the GOLD II, III and IV subjects, 124 (7.4%) subjects fall above the upper 90% prediction interval and represent a subset of patients with severity of FEV1 impairment below that which would be expected given their FEV1/FVC ratio. This group may represent a unique COPD phenotype with unique pathogenic characteristics, clinical symptoms, therapeutic responsiveness, and prognosis. |
Key Publications
Bon JM, Leader JK, Weissfeld JL, Coxson HO, Zheng B, Branch RA, Kondragunta V, Lee JS, Zhang Y, Choi AM, Lokshin AE, Kaminski N, Gur D, Sciurba FC. The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS One. 2009 Aug 31;4(8)
Bon JM, Weissfeld JL, Sciurba FC. A unique spirometric phenotype in COPD. Am J Respir Crit Care Med. 2008 Aug 15;178(4):431-2.