Department of Medicine

University of Pittsburgh

Division of Infectious Diseases

Office of the Division Chief
John W. Mellors, MD
3550 Terrace Street
Scaife Hall-Suite 818
Pittsburgh, PA 15261
Phone: 412-383-7963
Fax: 412-383-7982
Email: jwm1@pitt.edu
Assistant: Lois Mathews
Email: lmm112@pitt.edu

ID Administrative Offices
c/o Division Administrator
Lisa Gundel
3601 Fifth Avenue
Falk Medical Building
Suite 3A - Room 303
Pittsburgh, PA 15213-2582
Phone: 412-648-6593
Fax: 412-648-6399
Email: lgundel@mail.magee.edu
Assistant: Betty Edwards
Email: eae5@pitt.edu
Phone: 412-648-6273

PATIENT SCHEDULING
General Infectious Diseases Clinic
University of Pittsburgh Infectious Diseases Clinics
Falk Medical Building
3601 Fifth Avenue – 7th Floor Falk Medical Building
Pittsburgh, PA 15213
Appointments: 412-647-0996
Main ID Fax Number: 412-647-3162

HIV/AIDS Care Center
University of Pittsburgh Infectious Diseases
Falk Medical Building
3601 Fifth Avenue – 7th Floor Falk Medical Building
Pittsburgh, PA 15213

Pittsburgh AIDS Center for Treatment Clinic (PACT)
PACT Appointments: 412-647-7228 or 1-877-788-7228
PACT Fax Number: 412-647-7951

Pittsburgh Treatment and Evaluation Unit (PTEU)
PTEU Appointments: 412-647-8125 or 1-888-396-7838
PTEU Fax Number: 412-647-6253

Transplant Infectious Diseases Clinic
University of Pittsburgh Infectious Diseases Clinics
Falk Medical Building
3601 Fifth Avenue – 7th Floor Falk Medical Building
Pittsburgh, PA 15213
Appointments: 412-647-0996
ID Fax Number: 412-647-3162

ID Fellowship Coordinator
Kim Barnhart
University of Pittsburgh Infectious Diseases Clinics
Falk Medical Building
3601 Fifth Avenue – Suite 3A
Pittsburgh, PA 15213
Phone: 412-648-6406
Fax: 412-648-6399
Email: kib9@pitt.edu

John W. Mellors, MD
photo

Professor of Medicine

Chief, Division Infectious Diseases

Director, HIV/AIDS Program
Office: Scaife Hall, Suite 818
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-624-8512
Fax: 412-383-7982
E-mail: mellors@dom.pitt.edu
Education
BA, Dartmouth College, Hanover, NH, 1975
MD, Dartmouth Medical School, Hanover, NH, 1978
Training
Internship/Residency Training, Yale-New Haven Hospital, New Haven, CT, 1982
Infectious Diseases Fellowship Training, Yale University School of Medicine, New Haven, CT, 1985
Area of Specialization/Research Interest  
HIV antiviral drug resistance
Microbial Trials Network (MTN)
 
Profile
Dr. Mellors is a tenured Professor of Medicine, Pathology, and Infectious Diseases and Microbiology, and Chief of the Infectious Diseases Division. He directs the primary care and clinical research activities in HIV/AIDS at UPMC Health System, providing care to over 1000 HIV-infected individuals. He is the Principal Investigator on the Pittsburgh site for the Adult AIDS Clinical Trials Unit. The clinical trials unit has conducted pivotal trials of new antiretrovirals, including protease inhibitors, triple drug combinations, and combination protease inhibitors. Dr. Mellors' research as an investigator on the Multicenter AIDS Cohort Study has provided insight into the relationship between viral load and disease outcome. His laboratory has focused on the problem of HIV resistance to antiretroviral drugs. His work in this area has helped define the genetic and biochemical basis for HIV resistance. His laboratory developed recombinant retroviral systems to detect drug resistant HIV.
Research Link
Mellors Virology Laboratory
View Research Webpage
Recent Grants
Title: Rational Design of NRTI for Drug Resistant HIV-1
Role: Principal Investigator
Amount:
Funding Agency: NIH -In this project, we will perform in-depth studies of structure-activity relationships, cellular toxicity and resistance selection to identify the most promising clinical candidates from ADP class
Start Year: 2007
End Year: 2011
Title: Microbicide Trials Network - Central Lab
Role: Co-Investigator (PI: Hillier)
Amount:
Funding Agency: NIH - The major goal of this project is to establish the Central Lab consisting of 5 core laboratories for support of the Microbicide Trials Network's clinical evaluation of microbicide products.
Start Year: 2006
End Year: 2013
Title: Training in AIDS and Molecular Biology and Epidemiology
Role: Principal Investigator
Amount:
Funding Agency: HIV/NIAID T32-The goal of this grant is to provide rigorous research training in ID that provides postdoctoral physicians with critical experience necessary for successful investigative careers.
Start Year: 2005
End Year: 2010
Title: Multicenter AIDS Cohort Study: Viral Load Supplement
Role: Co-Investigator
Amount:
Funding Agency: NIH - Dr. Mellors is heading the part of this project that investigates the relationship between viral load and disease outcome.
Start Year: 2004
End Year: 2009
Title: Virology Support Laboratory for Adult AIDS Clinical Trials Group
Role: Principal Investigator
Amount:
Funding Agency: NIH-Social and Scientific Systems- Major goals of this project are to investigate the role of minor drug resistant viral variants in antiretroviral treatment failure.
Start Year: 2003
End Year: 2013
Title: NCI HIV Drug Resistance Program
Role: Principal Investigator
Amount:
Funding Agency: SAIC/NCI - the major goal of this project is to provide scientific support for key DRP studies on the mechanism and development of HIV resistance to antiviral drugs in the lab and in the clinic.
Start Year: 2001
End Year: 2009
Title: Adult AIDS Clinical Trials Unit
Role: Principal Investigator
Amount:
Funding Agency: NIH-The goal of this project is to design, enroll and analyze clinical trials to optimize antiretroviral therapy.
Start Year: 2000
End Year: 2013
Recent Peer-Reviewed Publications
Title: Class-sparing regimens for initial treatment of HIV-1 infection: ACTG 5142
Author(s): Riddler SA, Haubrich R, DiRienzo AG, Peeples L, Powderly WG, Klingman KL, Garren KW, George T, Mellors JW for the ACTG A5142 Team
Year: 2008
Journal: New Eng J Med
Volume: 358
Page(s): 2095-2106
Title: Prognostic value of HIV-1 RNA, CD4 cell count, and CD4 cell slope for progression to AIDS and death in untreated HIV-1 infection
Author(s): Mellors JW, Margolick JB, Phair JP, Rinaldo CR, Detels R, Jacobson LP, Munoz A
Year: 2007
Journal: JAMA
Volume: 297 (21)
Page(s): 2349-50
Title: Potential Impact of Antiretroviral Chemoprophylaxis on HIV-1 Transmission in Resource-Limited Settings
Author(s): Abbas UL, Anderson RM, Mellors JW
Year: 2007
Journal: PLoS ONE
Volume: 2(9) PMCID: PMC1975470
Page(s): 875
Title: Molecular Mechanisms of Bi-Directional Antagonism between K65R and Thymidine Analog Mutations in HIV-1 Reverse Transcriptase.
Author(s): Parikh UM, Zelina S, Sluis-Cremer N, Mellors JW
Year: 2007
Journal: AIDS
Volume: 21 PMID 17589186
Page(s): 1405-1414
Title: Molecular mechanism by which K70E in HIV-1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors
Author(s): Sluis-Cremer N, Sheen CW, Zelina S, Torres PSAQ, Parikh UM, Mellors JW
Year: 2007
Journal: Antimicrob Agents Chemother
Volume: 51 PMCID: PMC1797654
Page(s): 48-53
Title: ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia
Author(s): Maldarelli F, Palmer S, King MS, Wiegand A, Polis MA, Mican J, Kovacs JA, Davey RT, Mellors JW
Year: 2007
Journal: PLoS Pathog
Volume: 3(4) PMCID: PMC1847689
Page(s): 46
Title: Selection of Mutations in the Connection and RNase H Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase that Increase Resistance to 3'-Azido-3'-Dideoxythymidine
Author(s): Brehm J, Koontz D, Meteer JD, Pithak V, Sluis-Cremer N, Mellors JW
Year: 2007
Journal: J Virol
Volume: 81 PMCID PMC1951314
Page(s): 7852-9
Title: The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenylate mofetil in drug-resistant HIV infection
Author(s): Margolis DM, Mukherjee L, Fltecher CV, Hogg E, Ogata-Arakaki D, Petersen T, Russin D, Martinez A, Mellors JW for the ACTG 5165 Team
Year: 2007
Journal: AIDS
Volume: 21 PMID: 17885292
Page(s): 2025-2032
Title: The level of persistent HIV viremia does not increase after successful simplification of maintenance therapy to lopinavir/ritonavir alone
Author(s): McKinnon JE, Arribas JR, Pulido F, Delgado R, Mellors JW
Year: 2006
Journal: AIDS
Volume: 20
Page(s): 2331-5
Title: Randomized trial of treatment interruption prior to optimized antiretroviral therapy for persons with drug-resistant HIV: 48 week virologic results of ACTG A5086. J Inf Dis 2006; 194:1309-18
Author(s): Benson CA, Vaida F, Havlir DV, Downey GF, Lederman MM, Gulick RM, Glesby MJ, Wantman M, Mellors JW
Year: 2006
Journal: J Inf Dis
Volume: 194
Page(s): 1309-18
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