Department of Medicine

Department of Medicine

 Division of Infectious Diseases

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photo Nina Singh, MD

Transplant Infectious Diseases VA Pittsburgh Healthcare System


Phone: 412-360-1688

Office: VA Medical Center, Suite 2A-126
University Drive C
Pittsburgh, PA 15240
Phone: 412-360-1688
Fax: 412-360-6312
Education and Training
MD, Government Medical College, India, 1980
Internship, Montefiore University Hospital, Pittsburgh, PA, 1982
Residency Training, St. Francis Medical Center, Pittsburgh, PA, 1984
Infectious Diseases Fellowship, University of Pittsburgh, Pittsburgh, PA, 1987
Research Interest
Dr. Singh's area of research interest is opportunistic viral and fungal infections in organ transplant recipients. Her specific interests include herpes virus infections (cytomegalovirus and human herpesvirus-6) in transplant recipients. Her work in this area pertains to clinical trials to optimize antiviral prophylaxis and assess CMV-specific immune responses after transplantation. The knowledge gained from these studies has implications for elucidating the mechanistic basis for CMV disease despite current prophylactic practices and for designing immune-based therapies in the future as adjuncts to antivirals for the prevention of CMV. A key area of her research interest is invasive cryptococcosis in transplant recipients. Dr. Singh has conducted pivotal studies to assess risks, disease associations, outcomes, and immunopathogenesis as it relates to this yeast in transplant recipients. These studies have made a major contribution toward the scientific rationale for the Infectious Diseases Society of America (IDSA) and American Society of Transplantation (AST) guidelines for cryptococcus in transplantation. More recently, Dr. Singh's work has focused on characterizing immune reconstitution syndrome in organ transplant recipients with opportunistic infections and on understanding how manipulation of iatrogenic immunosuppressants has the ability to alter the host immunologic milieu, posing a risk for this poorly understood entity.
Clinical Interest
Nina Singh has approximately 30 years of hands-on experience in the management of complex cases and challenging issues in transplant recipients and candidates, and optimizing prophylactic and treatment approaches based upon evidence-based data in these hosts.
Selected Publications:
Singh N, Cryptococcal Collaborative Transplant Study Group. Pulmonary cryptococcosis in organ transplant recipients: clinical relevance of serum cryptococcal antigen. Clin Infect Dis. 2008; 46:e12-18.
Singh N, Aguado JM,, Bonatti H, Forrest G, Gupta KL, Safdar N, John GT, Pursell KJ, Muñoz P. Zygomycosis in solid organ transplant recipients: a prospective, matched case-control study to assess risks for disease and outcome. J Infect Dis. 2009; 200: 1002-11.
Sun HY, Wagener MM, Singh N. Cryptococcosis in solid-organ, hematopoietic stem cell, and tissue transplant recipients: evidence-based evolving trends. Clin Infect Dis. 2009; 48: 1566-76.
Sun HY, Aguado JM, Bonatti H, Forrest G, Gupta KL, Safdar N, John GT, Pursell KJ, Singh N for the Zygomycosis Transplant Study Group. Pulmonary zygomycosis in solid organ transplant recipients in the current era. Am J Transplant. 2009; 9: 2166-71.
Singh N, Dromer F, Perfect JR, Lortholary O. Cryptococcus in solid organ, hematopoietic stem cell and tissue allograft recipients: evidence-based review and evolving trends. Clin Infect Dis. 2008; 47: 1321-1327.
Singh N, Lortholary O, Dromer F, Alexander BD, Gupta KL, John GT, del Busto R, Klintmalm GB, Cryptococcal Collaborative Transplant Study Group. Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings. Transplantation. 2008; 56: 647-651.
Sun HY, Singh N. Emerging importance of infections due to zygomycetes in organ transplant recipients. Int J Antimicrob Agents. 2008; 32 (S2): 115-118.
Singh N. Novel immune regulatory pathways and their role in immune reconstitution syndrome in transplant recipients with invasive mycoses. Eur J Clin Microbiol Infect Dis. 2008; 27: 403-408.
Singh N, Perfect JR. Immune reconstitution syndrome and exacerbation of infections following pregnancy. Clin Infect Dis. 2007; 45: 1192-1199.
Kontoyiannis DP, Lewis RE, Alexander BD, Lortholary O, Dromer F, Gupta KL, John GT, del Busto R, Singh N. Calcineurin-inhibitor agents interact synergistically with antifungal agents in vitroagainst Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrob Agents Chemother 2008:52;735-738. Antimicrob Agents Chemother. 2008; 52: 735-738.
Sponsored Research/Activities
Title: Prophylaxis versus Preemptive Therapy for CMV in R-D+ Liver transplant Recipients
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: N01 HHSN272201100041C
Start Year: 2011
End Year: 2016
Notable Achievements
Poster of Distinction Award, American Transplant Congress, 2011
Editorial Board-Transplantation, Liver Transplantation, J Invasive Fungal Infections, and Virulence.
Associate Editor, Transplantation, 2014-2016
Member, Joint Research Awards Committee Infectious Diseases Society of America, 2011-2014
Lead Author - "Top 10 papers” 2013 Infectious Diseases Society of America
Lead Author - "Top 10 papers" 2014 Interscience Conference on Antimicrobial Agents an Chemotherapy
Pittsburgh Magazine, Best Doctors in America 2012, 2013, 2014, and 2016