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Department of Medicine

Department of Medicine

 Division of Infectious Diseases

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photo Deborah K. McMahon, MD

Professor of Medicine

Clinical Director, HIV/AIDS Care Center

Email: mcmahon@dom.pitt.edu

Phone: 412-383-1675

Contact
Office: Keystone Building, Suite 510
3520 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-383-1675
Fax: 412-383-2900
E-mail: mcmahon@dom.pitt.edu
Administrative Assistant:
Patricia Paulson
Email: ppaulson@pitt.edu
Phone: 412-383-1675
Education and Training
Education
BA, Seton Hill College, Greensburg, PA, 1977
MD, Temple University, Philadelphia, PA, 1981
Training
Internship/Residency Training, Maimonides Medical Center, New York, 1985
Infectious Diseases Fellowship, University of Pittsburgh, 1988
Research Interest
Dr. McMahon's research focuses on the HIV reservoir and eradication strategies. She currently serves as co-chair of two NIH-funded AIDS Clinical Trials Group studies. The first study examines the decay of the HIV reservoir in HIV­ infected patients receiving long-term antiretroviral therapy; its substudy intensively examines the reservoir in anatomic sites, such as the blood, gut-associated lymphatic tissue, and CSF. The second study evaluates the impact of a histone deactelyase inhibitor, romidepsin, on immune activation and HIV expression in HIV-infected patients suppressed on antiretroviral therapy. She is also site principal investigator for an NIH-funded study to examine the effects of rifaximin on immune activation and inflammation. She has over 25 years of HIV clinical research experience.
Clinical Interest
Dr. McMahon serves as Clinical Director of the UPMC HIV/AIDS Program, which provides comprehensive HIV primary care services to individuals living with HIV/AIDS in southwestern Pennsylvania. Men, women, and youth 18 years of age and older receive the full spectrum of HIV care at the Pittsburgh AIDS Center for Treatment (PACT), a National Center for Quality Assurance (NCQA)-designated Level 3 Patient-Centered Medical Home. She serves as Project Director for the HRSA funded-Ryan White Program and oversees a team of physicians, mental health specialists, HIV pharmacist, social workers, medical case manager, and nutritionist. Additionally, she leads a HRSA-funded Special Projects of National Significance (SPNS), designed to develop system-level workforce capacity building by integrating HIV primary care in a community health care setting. Finally, she is actively engaged in a major regional initiative, AIDS Free Pittsburgh, focused on dramatically reducing the incidence of new HIV infections and eliminating new AIDS diagnoses in Allegheny County by 2020.
Educational Interest
Dr. McMahon has a long-standing commitment to HIV/AIDS education and training. She serves as co-principal investigator for the HRSA-funded Mid Atlantic AIDS Education and Training Center, which provides HIV/AIDS education, consultation, technical assistance, and resource materials to health professionals throughout the region. She also mentors fellows, residents and students during their clinical rotations through PACT.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Cohen OJ, Pantaleo G, Holodniy, M, Fox CH, Orenstein JM, Schnittman S, Niu M, Graziosi C, Pavlakis GN, Lalezari J, Bartlett JA, Steigbigel RT, Cohn J, Novak R, McMahon DK, Fauci AS. Anti-retroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on viral load in lymphoid tissue. J Infect Dis. 1996; 173: 849-856.
Gulick RM, Mellors JW, Havlir D, Eron J, Ganzolez C, McMahon DK, Richman DD, Valentine F, Jonas L, Deutsch P, Meinbohm A, Holder D, Schleif W, Condra J, Emini E, Chodakewitz JA. Treatment with a combination of indinavir, zidovudine, and lamivudine in HIV-infected adults with prior antiretroviral use. N Engl J Med. 1997; 337: 734-739.
McMahon DK, Lederman M, Haas DW, Haubrich R, Stanford J, Cooney E, Horton J, Kelleher D, Ross L, Cutrell A, Lee D, Spreen W, Mellors JW. Antiretroviral activity and safety of abacavir in combination with selected HIV-1 protease inhibitors in therapy naïve HIV-1 infected adults. Antivir Ther. 2001; 6: 105-114.
McMahon DK, DiNubile MJ, Meibohm AR, Marino DR, Robertson MN for the Protocol 060 Study Group. Efficacy, Safety, and Tolerability of Long-Term Combination Antiretroviral Therapy in Asymptomatic Treatment-Naïve Adults with Early HIV Infection. HIV Clin Trials. 2007; 8: 269-281.
Blanchard-Horan C, J Hitti, E Ferguson, KL Klingman, D McMahon. Site Development and Capacity Building for Therapeutic Clinical Trials Targeting HIV-Positive Pregnant Women in Resource-Limited Settings: Challenges and Solutions. SoCRA Source. 2008; 2: 72.
Sponsored Research/Activities
Title: AIDS Clinical Trial Group: ACTG 5315-5321 Protocol Chair
Role: Principal Investigator
Funding Agency: Brigham and Women's Hospital, Inc./National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI068636
Start Year: 2014
End Year: 2016
Title: Effect of Interferon Alpha 2b Intensification on HIV-1 Residual Viremia in Individuals Suppressed on Antiretroviral Therapy (PITHA)
Role: Principal Investigator
Funding Agency: SAIC Frederick Cancer R&D Center
Start Year: 2011
End Year: 2014
Title: Quantifying Reversal of HIV - Latency and Elimination of Latently-Infected CD4+ T-Cells
Role: Co-Investigator
Funding Agency: Gilead Sciences, Inc
Grant Number: RES
Start Year: 2016
End Year: 2018
Title: Induction of HIV Expression by TLR-7 Antagonists
Role: Co-Investigator
Funding Agency: Janssen Pharm
Grant Number: RES
Start Year: 2016
End Year: 2017
Title: Pennsylvania/MidAtlantic AETC, HRSA
Role: Co-Investigator
Funding Agency: Health Research and Services Administration
Grant Number: U10 HA29295
Start Year: 2015
End Year: 2019
Title: Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Role: Co-Investigator
Funding Agency: National Heart, Lung, & Blood Institute
Grant Number: R56 HL128134
Start Year: 2015
End Year: 2016
Title: REPRIEVE A5332 and A5333s Protocol Funds
Role: Co-Investigator
Funding Agency: Massachusetts General Hospital/National Heart, Lung, & Blood Institute
Grant Number: U01 HL123336
Start Year: 2014
End Year: 2016
Title: Simplified Assays of Latent But Inducible HIV-1 Reservoirs
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI113102
Start Year: 2014
End Year: 2016
Title: Aids Clinical Trial Group: Core Funding
Role: Co-Investigator
Funding Agency: Brigham and Women's Hospital, Inc./National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI068636
Start Year: 2014
End Year: 2016
Title: New Approaches to Assessing HIV Reservoirs and Their Depletion
Role: Co-Investigator
Funding Agency: Johns Hopkins University
Grant Number: RES
Start Year: 2014
End Year: 2016
Title: Pitt-Ohio State - Georgetown Clinical Trials Unit
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI069494
Start Year: 2013
End Year: 2020
Title: Appalachian Tri-State Node
Role: Co-Investigator
Funding Agency: National Agency for Drug Abuse
Grant Number: U10 DA020036
Start Year: 2011
End Year: 2015
Title: Pennsylvania/MidAtlantic AETC, HRSA
Role: Co-Investigator
Funding Agency: Health Research and Services Administration
Start Year: 2010
End Year: 2015
Title: Appalachian Tri-State Node
Role: Co-Investigator
Funding Agency: National Agency for Drug Abuse
Grant Number: U10 DA020036
Start Year: 2010
End Year: 2015
Title: HIV/AIDS Care, Housing Prevention and Education Services
Role: Project Director
Funding Agency: Jewish Healthcare Foundation
Grant Number: RES 1113-0225
Start Year: 2011
End Year: 2018
Notable Achievements
UPMC ACES, 2012
Best Doctors, 2013-2016
Member, ACTG HIV Reservoirs and Viral Eradication Transformative Science Group