Department of Medicine
Faculty Profiles by Division

Department of Medicine

Faculty Profiles

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photo Deborah K. McMahon, MD

Infectious Diseases

Professor of Medicine

Clinical Director, HIV/AIDS Care Center

Email: mcmahond@pitt.edu

Phone: 412-383-1675

Contact
Office: Keystone Building, Suite 510
3520 Fifth Avenue
Pittsburgh, PA 15213
 
Phone: 412-383-1675
Fax: 412-383-2900
E-mail: mcmahond@pitt.edu
Administrative Assistant:
Ari Blackford-Rupp
Address: Keystone Bldg.
Keystone Bldg. 5th Floor
Pittsburgh, PA 15213
Email: akb121@pitt.edu
Phone: 412-383-1675
Fax: 412-383-2900
Education and Training
Education
BA, Seton Hill College, Greensburg, PA, 1977
MD, Temple University, Philadelphia, PA, 1981
Training
Internship/Residency Training, Maimonides Medical Center, New York, 1985
Infectious Diseases Fellowship, University of Pittsburgh, 1988
Research Interest
Dr. McMahon's research focuses on the HIV reservoir and eradication strategies. She currently serves as co-chair of two NIH-funded AIDS Clinical Trials Group studies. The first study examines the decay of the HIV reservoir in HIV­ infected patients receiving long-term antiretroviral therapy; its substudy intensively examines the reservoir in anatomic sites, such as the blood, gut-associated lymphatic tissue, and CSF. The second study evaluates the impact of a histone deactelyase inhibitor, romidepsin, on immune activation and HIV expression in HIV-infected patients suppressed on antiretroviral therapy. She is also site principal investigator for an NIH-funded study to examine the effects of rifaximin on immune activation and inflammation. She has over 25 years of HIV clinical research experience.
Clinical Interest
Dr. McMahon serves as Clinical Director of the UPMC HIV/AIDS Program, which provides comprehensive HIV primary care services to individuals living with HIV/AIDS in southwestern Pennsylvania. Men, women, and youth 18 years of age and older receive the full spectrum of HIV care at the Pittsburgh AIDS Center for Treatment (PACT), a National Center for Quality Assurance (NCQA)-designated Level 3 Patient-Centered Medical Home. She serves as Project Director for the HRSA funded-Ryan White Program and oversees a team of physicians, mental health specialists, HIV pharmacist, social workers, medical case manager, and nutritionist. Additionally, she leads a HRSA-funded Special Projects of National Significance (SPNS), designed to develop system-level workforce capacity building by integrating HIV primary care in a community health care setting. Finally, she is actively engaged in a major regional initiative, AIDS Free Pittsburgh, focused on dramatically reducing the incidence of new HIV infections and eliminating new AIDS diagnoses in Allegheny County by 2020.
Educational Interest
Dr. McMahon has a long-standing commitment to HIV/AIDS education and training. She serves as co-principal investigator for the HRSA-funded Mid Atlantic AIDS Education and Training Center, which provides HIV/AIDS education, consultation, technical assistance, and resource materials to health professionals throughout the region. She also mentors fellows, residents and students during their clinical rotations through PACT.
Publications
For my complete bibliography, Click Here.
Selected Publications:
McMahon D., Zheng L., Hitti J., Chan E. S., Hong F., Kabanda J., Taulo F., Kumarasamy N., Hughes M. D., Mellors J. W., Halvas E. K. Greater Suppression of Nevirapine Resistance with 21-vs. 7-day Antiretroviral Regimens after Intrapartum Single Dose Nevirapine for Prevention of Mother-to-Child Transmission. Clinical Infectious Diseases. 2013; 56(7).
Gandhi R. T., McMahon D. K., Bosch R. J., Lalama C. M., Cyktor J. C., Macatangay B. J., Rinaldo C. R., Riddler S. A., Hogg E., Godfrey C., Collier A. C., Eron J. J., Mellors J. W. Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation. Public Library of Science Pathogens. 2017; 13(4).
Spudich S., Robertson K. R., Bosch R. J., Gandhi R. T., Cyktor J. C., Mar H., Macatangay B. J., Lalama C. M., Rinaldo C., Collier A. C., Godfrey C., Eron J. J., McMahon D., Jacobs J. L., Koontz D., Hogg E., Vecchio A., Mellors J. W. Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance. Journal of Clinical Investigation. 2019; 129(8): 3339-3346.
McMahon D. K., Zheng L., Cyktor J. C., Aga E., Macatangay B. J., Godfrey C., Para M., Mitsuyasu R. T., Hesselgesser J., Dragavon J., Dobrowolski C., Karn J., Acosta E. P., Gandhi R. T., Mellors J. W. A Phase I/II Randomized, Placebo-Controlled Trial of Romidepsin in Persons with HIV-1 on Suppressive Antiretroviral Therapy to Assess the Safety and Activation of HIV-1 Expression (A5315). Journal of Clinical Investigation. 2020.
Bosch R. J., Gandhi R. T., Mar H., Eron J. J., Cyktor J. C., McMahon D. K., Mellors J. M. Associations Between Multiple Measures of HIV-1 Persistence in Persons on Suppressive Antiretroviral Therapy. Journal of Clinical Investigation. 2022; 225(12): 2163-2166.
Shehu A. I., Lu J., Wang P., Zhu J., Wang Y., Yang D., McMahon D., Xie W., Gonzalez F. J., Ma X. Pregnane X receptor activation potentiates ritonavir hepatotoxicity. Journal of Clinical Investigation. 2019; 129(7): 2898-2903.
Gandhi R. T., Cyktor J. C., Bosch R. J., Mar H., Laird G. M., Martin A., Collier A. C., Riddler S. A., Macatangay B. J., Rinaldo C. R., Eron J. J., Siliciano J. D., McMahon D. K., Mellors J. W. AIDS Clinical Trials Group A5321 Team. Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy. Journal of Clinical Investigation. 2021; 223(2): 225-233.
Enick P. N., Brooker J. P., Tumiotto C. M., Staines B. T., Eron J. J., McMahon D. K., Gandhi R. T., Mellors J. W., Sobolewski M. D. Comparison of methods to quantify inducible HIV-1 outgrowth. Journal of Virus Eradication. 2021; 7(2).
Gandhi R. T., Bosch R. J., Mar H., Laird G. M., Halvas E. K., Hovind L., Collier A. C., Riddler S. A., Martin A., Ritter K., McMahon D. K., Eron J. J., Cyktor J. C., Mellors J. W., AIDS Clinical Trials Group A5321 Team. Varied Patterns of Decay of Intact Human Immunodeficiency Virus Type 1 Proviruses Over 2 Decades of Antiretroviral Therapy. Journal of Clinical Investigation. 2023; 227(12): 1376-1380.
Sponsored Research/Activities
Title: COVID Convalescent Plasma Pittsburgh Program
Role: Co-Investigator
Funding Agency: Pittsburgh Foundation
Grant Number: RES MR2020
Start Year: 2020
End Year: 2021
Title: Pitt-Ohio State - Georgetown Clinical Trials Unit
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI069494
Start Year: 2013
End Year: 2020
Notable Achievements
UPMC ACES, 2012
Best Doctors, 2013-2016
Member, ACTG HIV Reservoirs and Viral Eradication Transformative Science Group