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Department of Medicine

Department of Medicine

 Division of Infectious Diseases

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photo Cornelius (Neil) J. Clancy, MD

Associate Professor of Medicine

Director, Mycology Program

Chief, Infectious Diseases Section, VA Pittsburgh Health Care System

Email: clancyn@dom.pitt.edu

Phone: 412-647-0996

Contact
Office: University of Pittsburgh, ID Division
3550 Fifth Avenue, Suite S867 Scaife Hall
Pittsburgh, PA 15261
 
Phone: 412-647-0996
Fax: 412-648-8455
E-mail: clancyn@dom.pitt.edu
Administrative Assistant:
Tanya Gonzales
Address: S869, Scaife Hall
3550 Terrace St.
Pittsburgh, PA 15261
Phone: 412-648-8510
Fax: 412-648-8455
Education and Training
Education
B.A, Natural Sciences, The Johns Hopkins University, Baltimore, MD, 1984
M.D., Washington University School of Medicine, 1991
Training
Residency, Internal Medicine, The Union Memorial Hospital, Baltimore MD, 1994
Chief Resident, Internal Medicine, The Union Memorial Hospital, Baltimore, MD, 1995
Fellowship, Infectious Diseases, University of Florida, 2000
Research Interest
Dr. Clancy's laboratories are interested in the molecular pathogenesis of invasive infections caused by the fungus Candida albicans.

Dr. Clancy's labs have implicated several novel genes in both organisms that contribute to the pathogenesis of candidiasis and aspergillosis. Biological processes related to these genes that are studied in the lab include histone methylation and transcriptional regulation, DNA damage responses, and phosphoinositide regulation.

In addition, he and Dr. Nguyen collaborate on research about mechanisms of antimicrobial resistance in bacteria and fungi and their clinical relevance.
Publications
Selected Publications:
Raman, SB, Nguyen, MH, Cheng, S, Badrane, H, Iczkowski, KA, Wegener, M, Gaffen, SL, Mitchell, AP, Clancy, CJ. A competitive infection model of hematogenously disseminated candidiasis in mice redefines the role of Candida albicans IRS4 in pathogenesis. Infection and Immunity. 2013; 81(5): 1430-8.
Badrane, H, Nguyen, MH, Clancy, CJ. Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans. Antimicrobial Agents and Chemotherapy. 2016; 60(6): 3591-600.
Shields, RK, Nguyen, MH, Press, EG, Cumbie, R, Driscoll, E, Pasculle, AW, Clancy, CJ. Rate of FKS Mutations among Consecutive Candida Isolates Causing Bloodstream Infection. Antimicrobial Agents and Chemootherapy. 2015; 59(12): 7465-70.
Clancy, CJ, Meslin, C, Badrane, H, Cheng, S, Losada, LC,, Nieman, WC, Vergidis, P, Clark, NL, Nguyen, MH. Candida albicans Transcriptional Profiling Within Biliary Fluid From a Patient With Cholangitis, Before and After Antifungal Treatment and Surgical Drainage Open Forum. Infectious Diseases. 2016; 3(3): doi:10.1093/ofid/ofw120.
Shankar, J, Nguyen, MH, Crespo, MM, Kwak, EJ, Lucas, SK, McHugh, KH, Mounaud, S, Alcorn, JF, Pilewski, JM, Shigemura, N, Kolls, JK, Nieman, WC, Clancy, CJ. Looking Beyond Respiratory Cultures: Microbiome-Cytokine Signatures of Bacterial Pneumonia and Tracheobronchitis in Lung Transplant Recipients. American Journal of Transplantation. 2016; 16(6): 1766-78.
Sponsored Research/Activities
Title: Ceftolozane-Tazobactam Against Pseudomonas Aeruginosa Clinical Isolates with Various Mechanisms of Resistance
Role: Principal Investigator
Funding Agency: Merck Sharp & Dohme Corporation
Grant Number: RES
Start Year: 2016
End Year: 2018
Title: Imaging and PK-PD of Micafungin at Site of Candida Glabrata Infection In Vivo
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI121555
Start Year: 2015
End Year: 2017
Title: Candida Albicans Responses to Antifungals and Cell Wall Stress
Role: Principal Investigator
Funding Agency: Veterans Administration
Grant Number: IPA
Start Year: 2014
End Year: 2018
Title: VA-IPA Hassan Badrane
Role: Principal Investigator
Funding Agency: Veterans Administration
Grant Number: IPA
Start Year: 2014
End Year: 2018
Title: Evolution of KPC-K. Pneumoniae that Persist in Patients on Prolonged Antibiotics
Role: Principal Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI111037
Start Year: 2014
End Year: 2016
Title: Financial Burden of Cytomegalovirus Mismatch (CMV Donor+/Recipient-) in Lung Transplant Recipients (LTR)
Role: Co-Investigator
Funding Agency: Astellas Pharma US
Grant Number: RES
Start Year: 2016
End Year: 2018
Title: Evaluation of In Vitro Activity of Fosfomycin Alone or in Combination with Newly Introduced ß-Lactam Agents Against Carbapenem-Resistant Pseudomonas Aeruginosa and Enterobacteriaceae Clinical Isolates
Role: Co-Investigator
Funding Agency: Zavante Therapeutics, Inc.
Grant Number: RES
Start Year: 2016
End Year: 2017
Title: Fungal Infections Post-Influenza Among Lung Transplant Recipients
Role: Co-Investigator
Funding Agency: Astellas Pharma US
Grant Number: RES
Start Year: 2015
End Year: 2017
Title: Candida Albicans Gene Expression During Intra-abdominal Infections
Role: Co-Investigator
Funding Agency: National Institute of Allergy & Infectious Diseases
Grant Number: R21 AI107290
Start Year: 2014
End Year: 2017
Title: Antibacterial Resistance Leadership Group: CREST
Role: Co-Investigator
Funding Agency: Duke University/National Institute of Allergy & Infectious Diseases
Grant Number: UM1 AI04681
Start Year: 2014
End Year: 2015
Title: IL-17 Receptor Signaling in the Oral Mucosa
Role: Co-Investigator
Funding Agency: National Institute of Dental/Craniofacial Research
Grant Number: R01 DE022550
Start Year: 2012
End Year: 2017