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Department of Medicine

Department of Medicine

 Division of Infectious Diseases

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photo Shaoji Cheng, MD

Email: chengs@dom.pitt.edu

Phone: 412-648-9928

Contact
Office: Scaife Hall, Suite 869
3550 Terrace Street
Pittsburgh, PA 15261
 
Phone: 412-648-9928
Fax: 412-648-8455
E-mail: chengs@dom.pitt.edu
Education and Training
Education
M.D., Bengbu Medical College, 1985
Ph.D., Beijing TB & Thoracic Tumor Institute, 1995
Training
Post-doctor, The Johns Hopkins University, 1998
Post-doctor, University of Florida, 1999
Assistant Scientist, University of Florida, 2007
Research Interest
Dr. Cheng’s research interests are the pathogenesis of Candida infection and the Enterobacter infection, as well as the mechanisms of antifungal drug resistance.
Publications
For my complete bibliography, Click Here.
Selected Publications:
Shaoji Cheng, Cornelius J. Clancy, Mary Ann Checkley, Martin Handfield, Jeffrey D. Hillman, Ann Progulske-Fox, Alfred S. Lewin, Paul L. Fidel, M. Hong Nguyen. Identification of Candida albicans genes induced during thrush offers insight into pathogenesis Molecular Microbiology.2003, 48:1275-1288. Molecular Microbiology. 2003; 48: 1275-1288.
Shaoji Cheng, M. Hong Nguyen, Zongde Zhang, Hongyan Jia, Martin Handfield, Cornelius J. Clancy. Evaluation of the roles of four candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus. Infection and Immunity. 2003; 71: 6101-6103.
M. Hong Nguyen, Shaoji Cheng, Cornelius J. Clancy. Assessment of Candida albicans genes induced during infections as a tool to understand pathogenesis. Med Mycol. 2004; 42(4): 293-304.
Hassan Badrane, Shaoji Cheng, M. Hong Nguyen, Hong Yan Jia, Zongde Zhang, Nghe Weisner, Cornelius J. Clancy. Candida albicans IRS4 contributes to hyphal formation and virulence after the initial stages of disseminated candidiasis. Microbiology. 2005; 151: 2923-2931.
Shaoji Cheng, Cornelius J Clancy, Mary Ann Checkley, Zongde Zhang, Karen L Wozniak, Kalpathi R. Seshan, Hong Yan Jia, Paul Fidel, Garry Cole. The role of Candida albicans NOT5 in virulence depends upon diverse host factors in vivo. Infection and Immunity. 2005; 73: 6101-6103.
Suresh Babu Raman, M. Hong Nguyen, Zongde Zhang, Shaoji Cheng, Hong Yan Jia, Nghe Weisner, Kenneth Iczkowski, Cornelius J. Clancy. Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis. Molecular Microbiology. 2006; 60: 697-709.
Shaoji Cheng, Cornelius J. Clancy, Zongde Zhang, Binghua Hao, Wei Wang, Kenneth A. Iczkowski, Michael A. Pfaller, M. Hong Nguyen. Uncoupling of Oxidative Phosphorylation Enables Candida albicans to Resist Killing by Phagocytes and Persist in Tissue. Cellular Microbiology. 2007; 9: 492-501.
Shaoji Cheng, Cornelius J Clancy, Katherine T. Nguyen, William Clapp, M. Hong Nguyen. A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. Antimicrobial Agents and Chemotherapy. 2007; 51(5): 1855-1858.
Cornelius J. Clancy, Minh-Ly Nguyen, Shaoji Cheng, Hong Huang, Guixiang Fan, Reia A. Jaber, John R. Wingard, Christina Cline, M. Hong Nguyen. IgG responses against a panel of Candida albicans antigens are accurate and early markers for systemic candidiasis. J. Clin. Microbiol. 2008; 46(5): 1647-1654.
H. Badrane, M. H. Nguyen, S. Cheng, V. Kumar, H. Derendorf, K. A. Iczkowski, C. J. Clancy. The Candida albicans phosphatase Inp51p interacts with the EH protein Irs4p and regulates phosphatidylinositol-4-5-bisphosphate levels, the cell integrity pathway, and virulence. Microbiology. 2008; 154(11): 3296-308.