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Department of Medicine

Department of Medicine

   Division of Infectious Diseases

Clinical


FMT Clinic


Fecal Microbiota Transplant (FMT)

Fecal Microbiota Transplant (FMT) is a novel therapy for the treatment of persistent or relapsing Clostridium difficile (C. difficile) infections. FMT involves the delivery of specially prepared stool (fecal) material from a healthy donor to a patient recipient. The transplanted fecal matter repopulates the recipient's gut bacterial microbiome with diverse microorganisms that re-establish a healthy environment and alleviate disease symptoms. In patients with recurrent C. difficile infection who have previously failed to recover following antibiotic therapy, FMT has been shown to be highly effective.
The FMT program at the University of Pittsburgh Medical Center (UPMC), which was founded in 2013, is a joint initiative between the Divisions of Infectious Diseases and Gastroenterology in the Department of Medicine. The primary clinical mission of the FMT program is to provide treatment to patients with recurrent C. difficile infections. Our success rate has been > 90 %, which is similar to cure rates across multiple centers in the United States. In April of 2016, we have launched a Volunteer Stool Bank Program, which is similar to the blood bank concept, and allows our patients to have on demand access to stool "treatment doses" from carefully selected healthy donors.

Who should consider FMT?

What does FMT involve?

Is FMT safe?

The Food and Drug Administration (FDA) has classified stool as biological agent and provided regulatory guidance for FMT to ensure patient safety. The primary focus of the FMT program at UPMC is the short- and long-term safety for our patients. This is accomplished through careful and extensive screening of both donors and recipients, and by handling fecal matter as a pharmaceutical substance in a dedicated PA Department of Health-approved FMT Laboratory. The manipulation of fecal material is performed in a biological safety cabinet using steam-sterilized, or single use sterile, equipment and reagents approved for patient care. The utmost care is invested to prevent contamination of the donor stool with other microorganisms, including environmental contamination.

How much does FMT cost?